Wu Shan, Lei Shu-Feng, Chen Xiang-Ding, Tan Li-Jun, Jian Wei-Xia, Deng Fei-Yan, Sun Xiao, Xiao Su-Mei, Jiang Cheng, Guo Yan-Fang, Zhu Xue-Zhen, Deng Hong-Wen
Hunan Normal University. Changsha, Hunan. P. R. China.
Ann Hum Biol. 2007 May-Jun;34(3):344-53. doi: 10.1080/03014460701275749.
Overweight or obese populations may have lower risk of osteoporotic fractures and higher bone mineral density (BMD), while bone strength is determined not only by bone material but also by bone structural parameters. Thus, the influence of body weight on bone geometry was examined in Chinese overweight adults.
The purpose of this study was to explore how total body lean mass (TBLM) and total body fat mass (TBFM) contribute to the variation of bone geometry at the femoral neck in Chinese overweight adults.
Bone geometric parameters including section modulus (Z), cross-sectional area (CSA), subperiosteal width (W), cortical thickness (CT) and buckling ratio (BR) were compared in 100 overweight (body mass index, BMI >/= 23) vs. 100 underweight subjects (BMI </= 18.5) in Chinese female and male adults aged 20-44 years by multiple regression analyses.
Multiple regression analysis revealed that both TBLM and TBFM were significantly higher in overweight subjects than in underweight subjects. Meanwhile, significant differences in bone geometric parameters (except W) were also detected between the overweight and underweight groups after adjustment for age and height in both sexes (p </= 0.001). Bone bending strength Z and axial strength CSA were 14% and 13% higher in females, as well as 18% and 20% higher in males in the overweight group than in the underweight group, respectively. The significant differences mentioned above were not observed when adjusted for TBLM, age, and height. TBLM seemed to be the strongest significant positive predictor of bone geometric parameters (p < 0.001), with the exception of W in both sexes and BR in females, while TBFM did not contribute significantly to the bone geometric parameters (p > 0.055 for both sexes).
Bone geometry may adapt primarily to mechanical load as represented by TBLM, but TBFM seemed to have no independent effect on bone geometry in Chinese overweight subjects.
超重或肥胖人群可能发生骨质疏松性骨折的风险较低且骨矿物质密度（BMD）较高，而骨强度不仅取决于骨材料，还取决于骨结构参数。因此，在中国超重成年人中研究了体重对骨几何形态的影响。
本研究旨在探讨全身瘦体重（TBLM）和全身脂肪量（TBFM）如何影响中国超重成年人股骨颈骨几何形态的变化。
通过多元回归分析，比较了100名超重（体重指数，BMI≥23）与100名体重过轻（BMI≤18.5）的20 - 44岁中国成年女性和男性的骨几何参数，包括截面模量（Z）、横截面积（CSA）、骨膜下宽度（W）、皮质厚度（CT）和屈曲比（BR）。
多元回归分析显示，超重受试者的TBLM和TBFM均显著高于体重过轻的受试者。同时，在对两性的年龄和身高进行调整后，超重和体重过轻组之间在骨几何参数（除W外）上也存在显著差异（p≤0.001）。超重组女性的骨弯曲强度Z和轴向强度CSA分别比体重过轻组高14%和13%，男性分别高18%和20%。在对TBLM、年龄和身高进行调整后，未观察到上述显著差异。TBLM似乎是骨几何参数最强的显著正预测因子（p<0.001），两性中除W以及女性中的BR外；而TBFM对骨几何参数没有显著贡献（两性p均>0.055）。
骨几何形态可能主要适应以TBLM表示的机械负荷，但在中国超重受试者中，TBFM似乎对骨几何形态没有独立影响。
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