Laboratoire de Physiologie et de Biomécanique de la Performance Motrice, Université de Balamand, Al Koura, Lebanon.
J Bone Miner Metab. 2010 Sep;28(5):595-600. doi: 10.1007/s00774-010-0176-1. Epub 2010 Apr 3.
Being overweight is associated with increased bone mineral content, bone mineral density (BMD), and bone strength in adults. However, the effect of being overweight on bone strength during adolescence is poorly understood. The aim of this study was to compare femoral neck geometry in overweight and normal weight adolescent girls. This study included 22 overweight (BMI > 25 kg/m(2)) adolescent girls (15.4 +/- 2.4 years old) and 20 maturation-matched (15.2 +/- 1.9 years old) controls (BMI < 25 kg/m(2)). Body composition and BMD were assessed by dual-energy X-ray absorptiometry (DXA). To evaluate bone geometry, DXA scans were analyzed at the femoral neck by the hip structure analysis (HSA) program. Cross-sectional area (CSA), an index of axial compression strength, section modulus (Z), an index of bending strength, cross-sectional moment of inertia (CSMI), cortical thickness (CT), and buckling ratio (BR) were measured from bone mass profiles. Lean mass, body weight, fat mass, and BMI were higher in overweight girls compared to controls (P < 0.001). CSA, Z, and CSMI were higher in overweight girls compared to controls (P < 0.05; P < 0.01 and P < 0.01, respectively). CT and BR were not significantly different between the two groups. After adjustment for body weight, lean mass, or fat mass, using a one-way analysis of covariance (ANCOVA), there were no differences between the two groups (overweight and controls) regarding the HSA variables (CSA, Z, CSMI, CT, and BR). In conclusion, this study suggests that overweight adolescent girls have greater indices of bone axial and bending strength in comparison to controls at the femoral neck.
超重与成年人的骨矿物质含量、骨密度（BMD）和骨强度增加有关。然而，超重对青春期骨强度的影响知之甚少。本研究旨在比较超重和正常体重青春期女孩的股骨颈几何形状。本研究包括 22 名超重（BMI>25kg/m²）的青春期女孩（15.4±2.4 岁）和 20 名成熟匹配的对照组（BMI<25kg/m²）（15.2±1.9 岁）。身体成分和 BMD 通过双能 X 射线吸收法（DXA）评估。为了评估骨几何形状，通过髋关节结构分析（HSA）程序对股骨颈的 DXA 扫描进行分析。来自骨质量曲线的横截面积（CSA）、轴向压缩强度指标、截面模量（Z）、弯曲强度指标、截面惯性矩（CSMI）、皮质厚度（CT）和屈曲比（BR）进行了测量。与对照组相比，超重女孩的瘦体重、体重、体脂量和 BMI 更高（P<0.001）。与对照组相比，超重女孩的 CSA、Z 和 CSMI 更高（P<0.05；P<0.01 和 P<0.01）。两组之间 CT 和 BR 没有显著差异。使用单向方差分析（ANCOVA），在校正体重、瘦体重或体脂量后，两组之间的 HSA 变量（CSA、Z、CSMI、CT 和 BR）没有差异（超重和对照组）。总之，本研究表明，与对照组相比，超重的青春期女孩股骨颈的骨轴向和弯曲强度指标更大。
