Polack F, Siverio C, Bigar F, Centifanto Y
Invest Ophthalmol. 1976 Mar;15(3):188-95.
Experiments were performed to study the fate of corneal grafts sensitized to herpes antigens when grafted to HSV-sensitized hosts. Nonsensitized grafts in systemically sensitized hosts remained clear, whereas all locally sensitized grafts in systemically sensitized hosts became opaque within ten days. The stroma showed severe lymphocytic and plasma cell infiltration and neovascularization. One-half of the corneas from systemically sensitized hosts grafted to eyes previously infected opacified in an accelerated manner. Round cells were found in the stroma and endothelium. The histological reaction in both groups was similar to that found in the immune graft reaction even though the clinical picture was not typical (peripheral and progressive edema with a rejection line). The accelerated reaction was probably related to the presence of virus antigens in graft stroma and subepithelial areas of the graft. The significance of HSV-sensitized donor tissue grafted onto HSV-sensitized hosts is discussed because of its possible implication in tissue transplantation.
进行了实验以研究对疱疹抗原致敏的角膜移植物移植到单纯疱疹病毒（HSV）致敏宿主时的转归。在全身致敏宿主中未致敏的移植物保持透明，而在全身致敏宿主中所有局部致敏的移植物在十天内变得混浊。基质显示严重的淋巴细胞和浆细胞浸润以及新生血管形成。将全身致敏宿主的角膜移植到先前感染过的眼睛上，其中一半角膜以加速的方式混浊。在基质和内皮中发现圆形细胞。两组的组织学反应与免疫移植物反应中发现的相似，尽管临床表现并不典型（周边和进行性水肿伴排斥线）。加速反应可能与移植物基质和移植物上皮下区域中病毒抗原的存在有关。由于其在组织移植中的可能影响，讨论了将HSV致敏的供体组织移植到HSV致敏宿主上的意义。
