文冠果壳中的三萜原皂苷元和原皂苷
Triterpenoid prosapogenols and prosapogenins from the husks of Xanthoceras sorbifolia.
作者信息
Li Z-L, Li X, Li D-Y, Li D, Meng D-L, Li W, Sha Y
机构信息
Research Department of Natural Medicines, Shenyang Pharmaceutical University, Shenyang 110016, China.
出版信息
J Asian Nat Prod Res. 2007 Apr-Aug;9(3-5):387-92. doi: 10.1080/10286020600782017.
Two new prosapogenins, 16-O-acetyl-21-O-(4-angeloyl)-alpha-l-rhamnopyranosyl barringtogenol C (1), 28-O-beta-d-glucopyranosyl 16-deoxybarringtogenol C (2), were isolated from the acid hydrolyzate of the crude saponin obtained from the husks of Xanthoceras sorbifolia Bunge, along with six known triterpenoids. These structures were established on the basis of chemical and detailed spectral evidences. Compounds 1 and 2 showed cytotoxic activity against human cell lines (A375-S2, HeLa).
从文冠果壳粗皂苷的酸水解产物中分离得到两个新的原皂苷元，16-O-乙酰基-21-O-(4-当归酰基)-α-L-鼠李吡喃糖基棒托皂苷元C（1）、28-O-β-D-吡喃葡萄糖基16-脱氧棒托皂苷元C（2），以及六个已知的三萜类化合物。这些结构是基于化学和详细的光谱证据确定的。化合物1和2对人细胞系（A375-S2、HeLa）显示出细胞毒性活性。
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