Department of Natural Products Chemistry, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shengyang 110016, People's Republic of China.
Bioorg Med Chem Lett. 2012 Aug 15;22(16):5232-8. doi: 10.1016/j.bmcl.2012.06.061. Epub 2012 Jun 28.
Xanthoceras sorbifolia Bunge is widely used as healthy food material and folk medicine in China. Phytochemical investigation on its seeds oil leavings has led to the isolation and identification of seven new oleanane-type triterpenoid saponins named sorbifoliasides A-F (1-6) and bunkankasaponin F (7), along with five known ones (8-12). The structures of the new compounds were elucidated through spectroscopic analysis and chemical derivatization. Among the isolated compounds, 16-oxo-3, 28-O-bidesmosidic triterpenoid saponins (2, 3, 5) were isolated from this plant for the first time. The cytotoxicity of all compounds against the ten selected human cancer cell lines was assayed. Compounds 7 and 9 showed significant activity against all the ten cancer cell lines (IC(50) <10 μM), while compounds 8, 10 and 11 exhibited moderate activity against most of these cancer cell lines.
文冠果是中国广泛用作健康食品材料和民间药物的树种。对其种仁油渣的植物化学研究导致了七种新的齐墩果烷型三萜皂苷的分离和鉴定，分别命名为 sorbifoliasides A-F（1-6）和 bunkankasaponin F（7），以及五种已知的化合物（8-12）。通过光谱分析和化学衍生化，确定了新化合物的结构。在分离出的化合物中，首次从该植物中分离到 16-氧-3,28-O-双糖基三萜皂苷（2,3,5）。对所有化合物对十种选定的人癌细胞系的细胞毒性进行了测定。化合物 7 和 9 对十种癌细胞系均显示出显著的活性（IC50<10 μM），而化合物 8、10 和 11 对大多数这些癌细胞系表现出中等活性。
