Formiga F R, Fonseca I A A, Souza K B, Silva A K A, Macedo J P F, Araújo I B, Soares L A L, Egito E Socrates T
Universidade Federal do Rio Grande do Norte, Programa de Pós Graduação em Ciências da Saúde, Laboratório de Sistemas Dispersos, Natal/RN, Brazil.
Int J Pharm. 2007 Nov 1;344(1-2):158-60. doi: 10.1016/j.ijpharm.2007.05.052. Epub 2007 May 29.
The aim of this work was to investigate the influence of a lipophilic drug, Ibuprofen, on the stability of o/w emulsions. Five formulations were prepared by the phase inversion temperature (PIT) method, and Ibuprofen was incorporated into their oil phase. Emulsion stability was evaluated by short- and long-term studies. Concerning the former, stability under centrifugation showed an improved profile for Ibuprofen-loaded emulsions. The latter confirmed such findings. In conclusion, a rather resistant interfacial film may take place when Ibuprofen was incorporated into the emulsions. Therefore, the critical hydrophilic-lipophilic-balance (HLB) of o/w emulsions can be affected by a lipophilic drug into their oil phase. Such approach is of great importance on the development of lipid carriers for therapeutic drug targeting.
这项工作的目的是研究亲脂性药物布洛芬对水包油型乳剂稳定性的影响。采用相转变温度（PIT）法制备了五种制剂，并将布洛芬加入到它们的油相中。通过短期和长期研究对乳剂稳定性进行评估。关于前者，离心稳定性显示含布洛芬的乳剂有更好的表现。后者证实了这些发现。总之，当布洛芬加入到乳剂中时，可能会形成相当稳定的界面膜。因此，水包油型乳剂的临界亲水亲油平衡（HLB）会受到油相中亲脂性药物的影响。这种方法对于治疗药物靶向脂质载体的开发具有重要意义。
