Jung Sun Hye, Park Hye Soon, Kim Kyung-Soo, Choi Woong H, Ahn Chul Woo, Kim Bom Taeck, Kim Seon Mee, Lee Seon Yeong, Ahn Sang Mi, Kim Yun Kyung, Kim Hae Jin, Kim Dae Jung, Lee Kwan-Woo
Department of Endocrinology and Metabolism, Ajou University School of Medicine, Yongtong Gu, Suwon 443-721, South Korea.
J Nutr Biochem. 2008 Jun;19(6):371-5. doi: 10.1016/j.jnutbio.2007.05.007. Epub 2007 Jul 5.
Obesity is a major risk factor for hypertension, coronary artery disease and type 2 diabetes. Weight loss is associated with significant metabolic benefits. Our objective was to examine changes in adipocytokines and interleukin (IL) 10 in obese subjects before and after weight loss. We measured anthropometric parameters, adipocytokine and IL-10 in 78 obese people who had visited obesity clinics at five university hospitals (Ajou, Ulsan, Catholic, Hanyang and Yonsei) in Korea. They restricted their caloric intake to less than their usual intake (by 500 kcal), were administered sibutramine and were given a program of exercise for 12 weeks. After 12 weeks, weight, body mass index, waist circumference, hip circumference, waist-to-hip ratio, total body fat, total cholesterol, triglyceride, tumor necrosis factor alpha (TNF-alpha), IL-6, resistin and leptin had significantly decreased, while adiponectin and IL-10 had significantly increased. A bivariate correlation analysis found that increment in IL-10 and baseline IL-10 levels significantly correlated with decrement in TNF-alpha (P<.01) and baseline adiponectin (r=.52, P<.001), respectively. These results were confirmed in a multiple regression analysis. The results suggest that weight loss after caloric restriction and medical treatment in obesity can improve metabolic risk factors through changes in some cytokines.
肥胖是高血压、冠状动脉疾病和2型糖尿病的主要风险因素。体重减轻与显著的代谢益处相关。我们的目标是研究肥胖受试者体重减轻前后脂肪细胞因子和白细胞介素（IL）-10的变化。我们测量了78名肥胖者的人体测量参数、脂肪细胞因子和IL-10，这些肥胖者曾就诊于韩国五所大学医院（亚洲大学、蔚山大学、天主教大学、汉阳大学和延世大学）的肥胖诊所。他们将热量摄入限制在低于平常摄入量（减少500千卡），服用西布曲明，并进行为期12周的运动计划。12周后，体重、体重指数、腰围、臀围、腰臀比、全身脂肪、总胆固醇、甘油三酯、肿瘤坏死因子α（TNF-α）、IL-6、抵抗素和瘦素显著下降，而脂联素和IL-10显著增加。双变量相关性分析发现，IL-10的增加和基线IL-10水平分别与TNF-α的下降（P<0.01）和基线脂联素的下降（r = 0.52，P<0.001）显著相关。这些结果在多元回归分析中得到证实。结果表明，肥胖者热量限制和药物治疗后的体重减轻可通过某些细胞因子的变化改善代谢风险因素。
