Budavari Judith M, Grayson Wayne
Division of Dermatology, Department of Medicine, University of the Witwatersrand, Johannesburg, South Africa.
Int J Dermatol. 2007 Jul;46(7):706-10. doi: 10.1111/j.1365-4632.2007.03141.x.
Papular and follicular eruptions, such as papulopruritic eruption, eosinophilic folliculitis, and infective folliculitis, are relatively common disorders in patients infected with the human immunodeficiency virus (HIV). These conditions may show considerable clinical overlap.
To assess the relative proportion of pruritic papular cutaneous eruptions in South Africans with HIV-associated dermatoses, and to correlate the clinical and histologic features of these lesions.
The clinical and histologic features of papular follicular eruptions were correlated in 40 consecutive black HIV-positive patients who underwent skin biopsy.
The clinical features were similar in all patients and consisted of widespread papules and pustules involving the face, limbs, and trunk. The most common histologic finding was acute suppurative folliculitis, seen in 27 patients (67.5%). In most cases, no cause was found for the suppuration. Papulopruritic eruption of HIV was diagnosed in six patients (15%), HIV-associated eosinophilic folliculitis in four (10%), Pityrosporum folliculitis in two (5%), and acne in one (2.5%). Concordance between the initial clinical diagnosis and the final histopathologic diagnosis was achieved in only 27.5% of cases.
Skin biopsy remains an important adjunct to the correct diagnosis and classification of papular and follicular eruptions in HIV-positive patients.
丘疹性和毛囊性皮疹，如丘疹性瘙痒性皮疹、嗜酸性毛囊炎和感染性毛囊炎，在感染人类免疫缺陷病毒（HIV）的患者中是相对常见的病症。这些情况可能在临床上有相当大的重叠。
评估南非HIV相关皮肤病患者中瘙痒性丘疹性皮肤疹的相对比例，并关联这些皮损的临床和组织学特征。
对40例连续接受皮肤活检的HIV阳性黑人患者的丘疹性毛囊性皮疹的临床和组织学特征进行关联分析。
所有患者的临床特征相似，包括累及面部、四肢和躯干的广泛丘疹和脓疱。最常见的组织学发现是急性化脓性毛囊炎，见于27例患者（67.5%）。在大多数情况下，未发现化脓原因。6例患者（15%）诊断为HIV相关丘疹性瘙痒性皮疹，4例（10%）为HIV相关嗜酸性毛囊炎，2例（5%）为马拉色菌毛囊炎，1例（2.5%）为痤疮。初始临床诊断与最终组织病理学诊断的一致性仅为27.5%。
皮肤活检仍然是正确诊断和分类HIV阳性患者丘疹性和毛囊性皮疹的重要辅助手段。
