Teofoli Patrizia, Barbieri Claudio, Pallotta Sabatino, Ferranti G, Puddu Pietro
Department of Immunodermatology, Istituto Dermopatico dell'Immacolata, IDI, IRCCS, Via Monti di Creta 104, 00167 Rome, Italy.
Eur J Dermatol. 2002 Nov-Dec;12(6):600-2.
Eosinophilic folliculitis (EF) is a rare follicular pruritic papular eruption observed in association with human immunodeficiency virus (HIV). The diagnosis of eosinophilic folliculitis is based on the histologic findings consisting of a sterile inflammatory infiltrate rich in eosinophils involving hair follicles. EF in HIV patients is believed to be an immunoinflammatory response directed either at follicular or skin flora antigens in the late-stage of HIV infection. In this stage, immune response is characterized by a shift from a Th1- to a Th2-dominant cytokine profile and an increased secretion of interleukin-4 and interleukin-5, both known to promote eosinophilia. We describe a case of HIV-associated eosinophilic folliculitis in a 30-year-old black woman referred to us for a pruritic follicular eruption without any other clinical symptom related to the acquired immunodeficiency syndrome. HIV infection presenting with EF has been rarely reported and its occurrence in women is also very rare.
嗜酸性粒细胞性毛囊炎（EF）是一种罕见的毛囊性瘙痒性丘疹性皮疹，与人类免疫缺陷病毒（HIV）感染相关。嗜酸性粒细胞性毛囊炎的诊断基于组织学表现，即由富含嗜酸性粒细胞的无菌性炎症浸润累及毛囊组成。HIV患者的EF被认为是HIV感染晚期针对毛囊或皮肤菌群抗原的免疫炎症反应。在这个阶段，免疫反应的特征是细胞因子谱从以Th1为主转变为以Th2为主，以及白细胞介素-4和白细胞介素-5分泌增加，这两种物质都已知可促进嗜酸性粒细胞增多。我们描述了一例30岁黑人女性的HIV相关嗜酸性粒细胞性毛囊炎病例，该患者因瘙痒性毛囊性皮疹前来就诊，无任何与获得性免疫缺陷综合征相关的其他临床症状。以EF为表现的HIV感染报道很少，其在女性中的发生也非常罕见。
