Nukui Kazuki, Yamagishi Toshihiko, Miyawaki Hiromi, Kettawan Aikkarach, Okamoto Tadashi, Sato Kiyoshi
Nisshin Pharma Inc., 25, Kanda-Nishiki-cho 1-chome, Chiyoda-ku, Tokyo 101-8441, Japan.
J Nutr Sci Vitaminol (Tokyo). 2007 Apr;53(2):187-90. doi: 10.3177/jnsv.53.187.
Coenzyme Q10 (CoQ10) is a lipid-soluble antioxidant and essential component of the mitochondrial electron transfer system in the body, and is in wide use as a functional food material and cosmetic raw material. However, as CoQ10 is extremely lipid-soluble, absorption by the body is not easy. In general, people use soft-gel capsules in which CoQ10 is suspended in oil, and take these capsules with food. PureSorb-Q40 (P40) was developed to improve CoQ10 processability and absorption when taken without food, and the present study compared the effects of food on absorption between P40 and conventional lipid-soluble CoQ10 in rats and humans. The results of a rat study showed higher uptake when P40 was administered in the fasting state or with food compared to lipid-soluble CoQ10. The results of a human study showed that uptake was favorable when P40 was administered in the fasting state, and even when administered postprandially, a significant difference was noted in uptake rate up to 6 h after intake and uptake volume up to 8 h after intake when compared to lipid-soluble CoQ10. These results show that any CoQ10 product using P40 can be quickly and reliably absorbed by the body regardless of dosage form or intake time.
辅酶Q10（CoQ10）是一种脂溶性抗氧化剂，是人体线粒体电子传递系统的重要组成部分，作为功能性食品原料和化妆品原料被广泛使用。然而，由于CoQ10具有极强的脂溶性，人体吸收并不容易。一般来说，人们使用CoQ10悬浮于油中的软胶囊，并与食物一起服用这些胶囊。研发了PureSorb-Q40（P40）以提高CoQ10在不与食物同服时的加工性能和吸收效果，本研究比较了食物对大鼠和人体中P40与传统脂溶性CoQ10吸收的影响。大鼠研究结果表明，与脂溶性CoQ10相比，在禁食状态或与食物一起给予P40时，其摄取量更高。人体研究结果表明，在禁食状态下给予P40时摄取良好，即使在餐后给予，与脂溶性CoQ10相比，摄入后6小时内的摄取率和摄入后8小时内的摄取量也有显著差异。这些结果表明，任何使用P40的CoQ10产品，无论剂型或摄入时间如何，都能被人体快速可靠地吸收。
