Bhagavan Hemmi N, Chopra Raj K
Tishcon Corporation, 30 New York Avenue, P.O. Box 331, Westbury, NY 11590, USA.
Mitochondrion. 2007 Jun;7 Suppl:S78-88. doi: 10.1016/j.mito.2007.03.003. Epub 2007 Mar 27.
Plasma coenzyme Q10 (CoQ10) response to oral ingestion of various CoQ10 formulations was examined. Both total plasma CoQ10 and net increase over baseline CoQ10 concentrations show a gradual increase with increasing doses of CoQ10. Plasma CoQ10 concentrations plateau at a dose of 2400 mg using one specific chewable tablet formulation. The efficiency of absorption decreases as the dose increases. About 95% of circulating CoQ10 occurs as ubiquinol, with no appreciable change in the ratio following CoQ10 ingestion. Higher plasma CoQ10 concentrations are necessary to facilitate uptake by peripheral tissues and also the brain. Solubilized formulations of CoQ10 (both ubiquinone and ubiquinol) have superior bioavailability as evidenced by their enhanced plasma CoQ10 responses.
研究了血浆辅酶Q10（CoQ10）对口服各种CoQ10制剂的反应。血浆总CoQ10和相对于基线CoQ10浓度的净增加均显示随着CoQ10剂量的增加而逐渐增加。使用一种特定的咀嚼片制剂时，血浆CoQ10浓度在2400毫克剂量时达到平稳状态。吸收效率随剂量增加而降低。循环中的CoQ10约95%以泛醇形式存在，摄入CoQ10后该比例无明显变化。需要更高的血浆CoQ10浓度以促进外周组织及大脑的摄取。CoQ10的增溶制剂（泛醌和泛醇）具有更高的生物利用度，这从它们增强的血浆CoQ10反应得到证明。
