Lanzetti Letizia
Dipartimento di Scienze Oncologiche, Università degli Studi di Torino, Istituto per la Ricerca e la Cura del Cancro, Str. Provinciale 142, 10060 Candiolo, Torino, Italy.
Curr Opin Cell Biol. 2007 Aug;19(4):453-8. doi: 10.1016/j.ceb.2007.04.017. Epub 2007 Jul 5.
Actin cytoskeleton remodeling provides the forces required for a variety of cellular processes based on membrane dynamics, such as endocytosis, exocytosis, and vesicular trafficking at the Golgi. All these events are coordinated by networks of associated proteins, and some of them are functionally connected with cell migration. The site and the duration of actin polymerization, in connection with vesicle budding and fusion, are tightly controlled by both small GTPases and the large GTPase dynamin. Recent advances in the understanding of the mechanisms coupling actin dynamics with membrane trafficking at the cell surface have been brought by the combined studies of actin polymerizing factors and of the endocytic/exocytic machinery.
肌动蛋白细胞骨架重塑为基于膜动力学的各种细胞过程提供所需的力，如内吞作用、外排作用以及高尔基体处的囊泡运输。所有这些事件都由相关蛋白网络协调，其中一些与细胞迁移功能相关。肌动蛋白聚合的位点和持续时间，与囊泡出芽和融合相关，受到小GTP酶和大GTP酶发动蛋白的严格控制。肌动蛋白聚合因子与内吞/外排机制的联合研究，为理解细胞表面肌动蛋白动力学与膜运输耦合机制带来了最新进展。
