苄胺组胺H(3)拮抗剂和5-羟色胺再摄取抑制剂。
Benzylamine histamine H(3) antagonists and serotonin reuptake inhibitors.
作者信息
Letavic Michael A, Stocking Emily M, Barbier Ann J, Bonaventure Pascal, Boggs Jamin D, Lord Brian, Miller Kirsten L, Wilson Sandy J, Carruthers Nicholas I
机构信息
Johnson & Johnson Pharmaceutical Research & Development LLC, 3210 Merryfield Row, San Diego, CA 92121, USA.
出版信息
Bioorg Med Chem Lett. 2007 Sep 1;17(17):4799-803. doi: 10.1016/j.bmcl.2007.06.061. Epub 2007 Jun 26.
PMID:17616397
Abstract
The design, synthesis, and in vitro activity of a series of novel 5-ethynyl-2-aryloxybenzylamine-based histamine H(3) ligands that are also serotonin reuptake transporters is described.
摘要
本文描述了一系列新型的基于5-乙炔基-2-芳氧基苄胺的组胺H(3)配体的设计、合成及其体外活性，这些配体同时也是5-羟色胺再摄取转运体。
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