具有5-羟色胺再摄取抑制剂活性的基于二胺的组胺H3拮抗剂的合成及生物学评价
Synthesis and biological evaluation of diamine-based histamine H3 antagonists with serotonin reuptake inhibitor activity.
作者信息
Stocking Emily M, Miller Jennifer M, Barbier Ann J, Wilson Sandy J, Boggs Jamin D, McAllister Heather M, Wu Jiejun, Lovenberg Timothy W, Carruthers Nicholas I, Wolin Ronald L
机构信息
Johnson & Johnson Pharmaceutical Research & Development, L.L.C., 3210 Merryfield Row, San Diego, CA 92121, USA.
出版信息
Bioorg Med Chem Lett. 2007 Jun 1;17(11):3130-5. doi: 10.1016/j.bmcl.2007.03.034. Epub 2007 Mar 15.
PMID:17412583
Abstract
The synthesis and structure-activity relationships of a series of novel phenoxyphenyl diamine derivatives with affinity for both the histamine H(3) receptor and the serotonin transporter is described.
摘要
描述了一系列对组胺H(3)受体和5-羟色胺转运体均具有亲和力的新型苯氧基苯基二胺衍生物的合成及其构效关系。
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