Stauber Roland H, Mann Wolf, Knauer Shirley K
Department of Otorhinolaryngology, Molecular and Cellular Oncology, University of Mainz, Mainz, Germany.
Cancer Res. 2007 Jul 1;67(13):5999-6002. doi: 10.1158/0008-5472.CAN-07-0494.
Survivin's proposed dual role as an apoptosis inhibitor and a mitotic effector positioned it in the front line of cancer research. Notably, survivin is detected as a cytoplasmic and nuclear protein in cancer patients, which stimulated numerous studies to investigate and to speculate on the functional and prognostic significance of its dynamic localization. Recent evidence shows that the direct interaction of survivin with the nuclear export receptor Crm1 is critically involved in its intracellular localization and cancer-relevant functions. Here, we review our current understanding of the Crm1/survivin interface and discuss its potential prognostic and therapeutic relevance.
生存素作为一种凋亡抑制剂和有丝分裂效应因子的双重作用使其处于癌症研究的前沿。值得注意的是，在癌症患者中检测到生存素是一种细胞质和细胞核蛋白，这激发了大量研究来探究并推测其动态定位的功能和预后意义。最近的证据表明，生存素与核输出受体Crm1的直接相互作用在其细胞内定位和癌症相关功能中起着关键作用。在此，我们综述了目前对Crm1/生存素界面的理解，并讨论了其潜在的预后和治疗相关性。
