血管细胞黏附分子-1在肿瘤免疫逃逸中的作用。
The role of vascular cell adhesion molecule-1 in tumor immune evasion.
作者信息
Wu T-C
机构信息
Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21231, USA.
出版信息
Cancer Res. 2007 Jul 1;67(13):6003-6. doi: 10.1158/0008-5472.CAN-07-1543.
Abstract
Tumor immune escape is a critical trait of cancer but the mechanisms involved have yet to fully emerge. One recent study has shown that tumor cells can escape T-cell immunity by overexpressing the endothelial cell adhesion molecule vascular cell adhesion molecule-1 (VCAM-1), which normally mediates leukocyte extravasion to sites of tissue inflammation. Renal cell carcinoma (RCC) was identified as one tumor type where VCAM-1 is commonly highly overexpressed. Together, our findings suggest that RCCs might exploit VCAM-1 overexpression for immune escape.
摘要
肿瘤免疫逃逸是癌症的一个关键特征，但其涉及的机制尚未完全明确。最近的一项研究表明，肿瘤细胞可通过过度表达内皮细胞粘附分子血管细胞粘附分子-1（VCAM-1）来逃避T细胞免疫，该分子通常介导白细胞外渗至组织炎症部位。肾细胞癌（RCC）被确定为一种VCAM-1通常高度过度表达的肿瘤类型。综合来看，我们的研究结果表明，肾细胞癌可能利用VCAM-1的过度表达来实现免疫逃逸。
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