Weng Francis L, Shults Justine, Leonard Mary B, Stallings Virginia A, Zemel Babette S
Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, USA.
Am J Clin Nutr. 2007 Jul;86(1):150-8. doi: 10.1093/ajcn/86.1.150.
Serum 25-hydroxyvitamin D [25(OH)D] concentrations serve as a biomarker for vitamin D stores. Prior studies have not examined the risk factors for low vitamin D concentrations in a multiethnic sample of US youth across a broad age range.
The objective was to determine the prevalence of and factors associated with low concentrations of 25(OH)D in children and adolescents.
Serum 25(OH)D concentrations were measured in 382 healthy children aged 6-21 y living in the northeastern United States. Dietary and supplemental vitamin D intake was assessed by interview. Fat and lean mass were assessed by dual-energy X-ray absorptiometry. Multivariable ordinal logistic regression was used to determine factors associated with decreased concentrations of 25(OH)D.
The median concentration of 25(OH)D was 28 ng/mL (interquartile range: 19-35 ng/mL), and 55% of subjects had 25(OH)D concentrations <30 ng/mL. 25(OH)D concentrations were inversely correlated with parathyroid hormone concentrations (Spearman's r=-0.31, P<0.001) but were not significantly correlated with 1,25-dihydroxyvitamin D concentrations. In the multivariable model, older age (P<0.001), black race [odds ratio (OR): 14.2; 95% CI: 8.53, 23.5], wintertime study visit (OR: 3.55; 95% CI: 2.29, 5.50), and total daily vitamin D intake <200 IU (OR: 1.58; 95% CI: 1.02, 2.46) were associated with low vitamin D concentrations. Fat and lean mass were not independently associated with vitamin D status in this healthy-weight sample.
Low serum 25(OH)D concentrations are prevalent in otherwise healthy children and adolescents in the northeastern United States and are related to low vitamin D intake, race, and season.
血清25-羟维生素D [25(OH)D] 浓度可作为维生素D储备的生物标志物。既往研究尚未在广泛年龄范围内的美国多民族青年样本中考察维生素D浓度低的风险因素。
确定儿童和青少年中25(OH)D浓度低的患病率及其相关因素。
对居住在美国东北部的382名6至21岁健康儿童的血清25(OH)D浓度进行了测量。通过访谈评估饮食和补充维生素D的摄入量。采用双能X线吸收法评估脂肪量和瘦体量。使用多变量有序逻辑回归来确定与25(OH)D浓度降低相关的因素。
25(OH)D的中位数浓度为28 ng/mL（四分位间距：19 - 35 ng/mL），55%的受试者25(OH)D浓度<30 ng/mL。25(OH)D浓度与甲状旁腺激素浓度呈负相关（Spearman相关系数r = -0.31，P<0.001），但与1,25-二羟维生素D浓度无显著相关性。在多变量模型中，年龄较大（P<0.001）、黑人种族 [比值比（OR）：14.2；95%置信区间（CI）：8.53，23.5]、冬季研究访视（OR：3.55；95% CI：2.29，5.50）以及每日维生素D总摄入量<200 IU（OR：1.58；95% CI：1.02，2.46）与维生素D浓度低有关。在这个体重正常的样本中，脂肪量和瘦体量与维生素D状态无独立相关性。
在美国东北部，血清25(OH)D浓度低在其他方面健康的儿童和青少年中普遍存在，且与维生素D摄入量低、种族和季节有关。
