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维生素D水平:我们只需要在患病时评估吗?

Vitamin D Levels: Do We Need to Assess Only in Disease?

作者信息

Jamwal Sunil, Gupta Kapil, Sidhu Tanvir Kaur

机构信息

Department of Biochemistry, Centre for Interdisciplinary Biomedical Research, Adesh University, Bathinda, Punjab, India.

Department of Biochemistry, AIMSR, Adesh University, Bathinda, Punjab, India.

出版信息

Int J Appl Basic Med Res. 2018 Oct-Dec;8(4):227-230. doi: 10.4103/ijabmr.IJABMR_105_18.

Abstract

BACKGROUND

Vitamin D is conventionally known as sunshine vitamin and is synthesized endogenously in sunlight. Vitamin D is known to be a key regulator of bone metabolism, the function of genes, and essential for the development of the whole body. Deficiency of Vitamin D is now become a major worldwide epidemic health problem.

AIM

The present study was conducted with the objective of determining the prevalence of Vitamin D deficiency (VDD) in urban population of a district in south Punjab, across various characteristics of population such as gender, age, and socioeconomic status.

MATERIALS AND METHODS

A cross-sectional population survey was conducted in the urban population of the district. A total of 120 healthy volunteers of either sex participated and their 25-hydroxy Vitamin D concentrations in serum samples were estimated using ELISA. The participants were divided into three categories as follows: Vitamin D deficient, insufficient, or sufficient, on the basis of normal standardized serum levels of Vitamin D <20, 20-30, and >30 ng/ml, respectively.

RESULTS

Of 120 healthy individuals, 95% of the study participants had VDD or insufficiency and only 5% had adequate Vitamin D levels. In each age group, females showed lower Vitamin D levels as compared to males. Furthermore, high body mass index value was associated with low Vitamin D. Upper-class individuals also showed low levels of Vitamin D as compared to other socioeconomic classes' individuals.

CONCLUSIONS

Overall, high prevalence of VDD among the apparently healthy urban population of the district was observed and gives an alarming sign about continuously increasing prevalence of hypovitaminosis D among healthy population.

摘要

背景

维生素D通常被称为阳光维生素,可在阳光下内源性合成。维生素D是骨代谢、基因功能的关键调节因子,对全身发育至关重要。维生素D缺乏现已成为一个主要的全球流行性健康问题。

目的

本研究旨在确定旁遮普邦南部某地区城市人口中维生素D缺乏症(VDD)的患病率,涵盖人口的各种特征,如性别、年龄和社会经济地位。

材料与方法

在该地区城市人口中进行了一项横断面人口调查。共有120名男女健康志愿者参与,使用酶联免疫吸附测定法(ELISA)估计其血清样本中25-羟基维生素D的浓度。根据维生素D正常标准化血清水平分别<20、20 - 30和>30 ng/ml,将参与者分为以下三类:维生素D缺乏、不足或充足。

结果

在120名健康个体中,95%的研究参与者患有VDD或不足,只有5%的人维生素D水平充足。在每个年龄组中,女性的维生素D水平低于男性。此外,高体重指数值与低维生素D水平相关。与其他社会经济阶层的个体相比,上层阶级个体的维生素D水平也较低。

结论

总体而言,该地区明显健康的城市人口中VDD患病率较高,这为健康人群中维生素D缺乏症患病率持续上升敲响了警钟。

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本文引用的文献

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Vitamin D Deficiency: Is The Pandemic for Real?维生素D缺乏:这一流行病是真的吗?
Indian J Community Med. 2015 Oct-Dec;40(4):215-7. doi: 10.4103/0970-0218.164378.
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Bone health in healthy Indian population aged 50 years and above.50 岁及以上印度健康人群的骨骼健康。
Osteoporos Int. 2011 Nov;22(11):2829-36. doi: 10.1007/s00198-010-1507-8. Epub 2011 Jan 27.
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Vitamin D insufficiency.维生素 D 不足。
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