Durá-Travé Teodoro, Gallinas-Victoriano Fidel, Peñafiel-Freire Diego Mauricio, Urretavizcaya-Martinez María, Moreno-González Paula, Chueca-Guindulain María Jesús
Department of Pediatrics, School of Medicine, University of Navarra, 31008 Pamplona, Spain.
Department of Pediatrics, Navarra Hospital Complex, 31008 Pamplona, Spain.
Children (Basel). 2020 Feb 1;7(2):10. doi: 10.3390/children7020010.
BACKGROUND/OBJECTIVES: Obesity is associated with cardiometabolic risk factors and with Vitamin D deficiency. The aim of this study was to examine the relationship between 25(OH)D concentrations and cardiometabolic risk factors in adolescents with severe obesity.
SUBJECTS/METHODS: A cross-sectional clinical assessment (body mass index, fat mass index, fat-free mass index, waist-to-height ratio, and blood pressure) and metabolic study (triglycerides, total cholesterol, HDL-C, LDL-C, glucose, insulin, HOMA-IR, leptin, calcium, phosphorous, calcidiol, and PTH) were carried out in 236 adolescents diagnosed with severe obesity (BMI z-score > 3.0, 99th percentile), aged 10.2-15.8 years. The criteria of the US Endocrine Society were used for the definition of Vitamin D status.
Subjects with Vitamin D deficiency had significantly elevated values ( < 0.05) for BMI z-score, waist circumference, waist z-score, body fat percentage, fat mass index, systolic and diastolic blood pressure, total cholesterol, triglycerides, LDL-C, insulin, HOMA-IR, leptin, and PTH than subjects with normal Vitamin D status. There was a significant negative correlation ( < 0.05) of serum 25(OH)D levels with body fat percentage, FMI, systolic BP, total cholesterol, triglyceride, LDL-C, glucose, insulin, HOMA-IR, leptin, and PTH.
Low Vitamin D levels in adolescents with severe obesity were significantly associated with some cardiometabolic risk factors, including body mass index, waist circumference, fat mass index, high blood pressure, impaired lipid profile, and insulin resistance.
背景/目的：肥胖与心血管代谢危险因素以及维生素D缺乏有关。本研究旨在探讨重度肥胖青少年中25(OH)D浓度与心血管代谢危险因素之间的关系。
对象/方法：对236名年龄在10.2 - 15.8岁、被诊断为重度肥胖（BMI z评分>3.0，第99百分位数）的青少年进行了横断面临床评估（体重指数、脂肪量指数、去脂体重指数、腰高比和血压）和代谢研究（甘油三酯、总胆固醇、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇、血糖、胰岛素、胰岛素抵抗指数、瘦素、钙、磷、骨化二醇和甲状旁腺激素）。采用美国内分泌学会的标准来定义维生素D状态。
维生素D缺乏的受试者在BMI z评分、腰围、腰z评分、体脂百分比、脂肪量指数、收缩压和舒张压、总胆固醇、甘油三酯、低密度脂蛋白胆固醇、胰岛素、胰岛素抵抗指数、瘦素和甲状旁腺激素方面的值显著升高（<0.05），高于维生素D状态正常的受试者。血清25(OH)D水平与体脂百分比、脂肪量指数、收缩压、总胆固醇、甘油三酯、低密度脂蛋白胆固醇、血糖、胰岛素、胰岛素抵抗指数、瘦素和甲状旁腺激素之间存在显著负相关（<0.05）。
重度肥胖青少年中低维生素D水平与一些心血管代谢危险因素显著相关，包括体重指数、腰围、脂肪量指数、高血压、血脂异常和胰岛素抵抗。
