棕榈酸三十烷酯作为脲酶抑制剂的动力学研究
Kinetics studies on triacontanyl palmitate: a urease inhibitor.
作者信息
Lodhi Muhammad Arif, Abbasi Muhammad Athar, Choudhary Muhammad Iqbal, Ahmad Viqar Uddin
机构信息
Dr Panjwani Center for Molecular Medicine and Drug Research, HEJ Research Institute of Chemistry, International Center for Chemical Sciences, University of Karachi, Karachi-75270, Pakistan.
出版信息
Nat Prod Res. 2007 Jul 10;21(8):721-5. doi: 10.1080/14786410600906913.
The mechanism of inhibition of jack bean and Bacillus pasteurii ureases was investigated by triacontanyl palmitate (1) which is a long-chain fatty ester and has been isolated from Symplocos racemosa Roxb. Lineweaver-Burk, Dixon plots, and their secondary replots showed that 1 is a non-competitive inhibitor of these enzymes. K(i) values were found to be 60.03 +/- 1.72 and 88.23 +/- 0.31 microM against jack bean and B. pasteurii ureases, respectively.
通过从总序山矾（Symplocos racemosa Roxb.）中分离得到的长链脂肪酸酯三十烷基棕榈酸酯（1），研究了其对刀豆脲酶和巴氏芽孢杆菌脲酶的抑制机制。Lineweaver - Burk图、Dixon图及其二级重绘图表明，1是这些酶的非竞争性抑制剂。发现其对刀豆脲酶和巴氏芽孢杆菌脲酶的抑制常数（K(i)）值分别为60.03±1.72μM和88.23±0.31μM。
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