Ashiralieva Ainura, Kleiner Diethelm
Mikrobiologie, Universität Bayreuth, 95440 Bayreuth, Germany.
FEBS Lett. 2003 Dec 4;555(2):367-70. doi: 10.1016/s0014-5793(03)01289-4.
Polyhalogenated benzo- and naphthoquinones were found to be potent inhibitors of pure ureases from Bacillus pasteurii and Canavalia ensiformis. They also inhibited ureases in whole cells of Helicobacter pylori, Klebsiella oxytoca and Proteus mirabilis. Inhibition was non-competitive with K(i) values in the micromolar range or below. Inhibition was irreversible as shown by equilibrium dialysis. Inhibitory power decreased considerably when halogens were replaced by -OH, -CN, alkoxy or alkyl groups.
多卤代苯醌和萘醌被发现是巴氏芽孢杆菌和刀豆中纯脲酶的有效抑制剂。它们还能抑制幽门螺杆菌、产酸克雷伯菌和奇异变形杆菌全细胞中的脲酶。抑制作用为非竞争性，抑制常数（Ki）值在微摩尔或更低范围内。平衡透析表明抑制作用是不可逆的。当卤素被-OH、-CN、烷氧基或烷基取代时，抑制能力显著降低。
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