Yousem Samuel A, Beasley Mary Beth
Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
Arch Pathol Lab Med. 2007 Jul;131(7):1027-32. doi: 10.5858/2007-131-1027-BCAROC.
The concept of bronchioloalveolar carcinoma underwent considerable refinement between the publications of the 1981 and 1999 World Health Organization classifications of lung tumors. Both pathologic and clinical aspects of this carcinoma are the subject of considerable interest.
To review and summarize the evolution of the current concept of bronchioloalveolar carcinoma and evolving issues that are under further investigation.
Pertinent peer-reviewed literature emphasizing historical classification and evolution as well as current and evolving concepts.
Small, solitary, nonmucinous bronchioloalveolar carcinomas are associated with a markedly better prognosis compared with conventional invasive adenocarcinomas. Such tumors may be cured by surgical resection and may be more responsive to epidermal growth factor receptor-targeted therapy. The prognosis and staging of multifocal disease remain unresolved, as does the question of whether a small amount of invasion adversely affects prognosis. Mucinous bronchioloalveolar carcinoma appears to be a markedly different entity than the nonmucinous subtype.
细支气管肺泡癌的概念在1981年和1999年世界卫生组织肺肿瘤分类出版物之间经历了相当大的细化。这种癌的病理和临床方面都是备受关注的主题。
回顾并总结细支气管肺泡癌当前概念的演变以及正在进一步研究的新出现问题。
强调历史分类与演变以及当前和新出现概念的相关同行评审文献。
与传统浸润性腺癌相比，小的、孤立的、非黏液性细支气管肺泡癌的预后明显更好。此类肿瘤可通过手术切除治愈，并且可能对表皮生长因子受体靶向治疗更敏感。多灶性疾病的预后和分期仍未解决，少量浸润是否会对预后产生不利影响的问题也是如此。黏液性细支气管肺泡癌似乎与非黏液性亚型明显不同。
