Cassel Jean-Christophe, Ben Hamida Sami, Jones Byron C
LINC UMR 7191, Université Louis Pasteur-CNRS, Institut Fédérératif de Recherche 37-GDR CNRS 2905, 12 rue Goethe, F-67000 Strasbourg, France.
Eur J Pharmacol. 2007 Oct 1;571(2-3):152-5. doi: 10.1016/j.ejphar.2007.06.006. Epub 2007 Jun 13.
In rats, at ambient temperatures of 21-23 degrees C, ethanol can attenuate the hyperpyretic effects of MDMA. We assessed if this attenuation holds true at a high ambient temperature. Rats were given MDMA (6.6 mg/kg i.p.) with or without ethanol (1.5 g/kg i.p.) at a room temperature of 32 degrees C. In the MDMA and ethanol+MDMA rats, body temperatures rose to about 42 degrees C after 60 min; all these rats had died after 120 min. At 23 degrees C, however, there was no lethality and ethanol reduced the hyperthermia. Thus, the effects of ethanol on MDMA-induced hyperthermia are related to ambient temperature.
