Seress L, Gulyás A I, Freund T F
Department of Physiology, University Medical School Pécs, Hungary.
J Comp Neurol. 1991 Nov 1;313(1):162-77. doi: 10.1002/cne.903130112.
Calcium-binding proteins calbindin D28k (CaBP) and parvalbumin (PV) were localized in neurons of the monkey hippocampal formation. CaBP immunoreactivity is present in all granule cells and in a large proportion of CA1 and CA2 pyramidal neurons, as well as in a distinct population of local circuit neurons. In the dentate gyrus, CaBP-immunoreactive nongranule cells are present in the molecular layer and in the hilar region, but they do not include the pyramidal basket cells at the hilar border. In the Ammon's horn, CaBP-positive, nonpyramidal neurons are more frequent in the CA3 area than in any other parts of the hippocampal formation. They are concentrated in the strata oriens and pyramidale of areas CA1-3, whereas only a few small neurons were found in the strata lucidum and radiatum of CA3 and in the stratum moleculare of the CA1 area. PV is exclusively present in local circuit neurons both in the dentate gyrus and in Ammon's horn. In the dentate gyrus the presumed basket cells at the hilar border exhibit PV immunoreactivity. In the hilar region and molecular layer only a relatively small number of cells are immunoreactive for PV. Most of these PV-positive cell bodies are located in the inner half of the molecular layer, with occasional horizontal cells at the hippocampal fissure. In Ammon's horn, strata oriens and pyramidale of areas CA1-3 contain a large number of PV-positive cells. There are no PV-immunoreactive cells in the strata lucidum, radiatum, or lacunosum moleculare. The CaBP- and PV-containing neurons form different subpopulations of cells in the monkey hippocampal formation. With the exception of a basket cell type in the monkey dentate gyrus, the CaBP- and PV-positive cell types were found to be remarkably similar in rodents and primates.
钙结合蛋白钙结合蛋白D28k（CaBP）和小白蛋白（PV）定位于猴海马结构的神经元中。CaBP免疫反应性存在于所有颗粒细胞以及大部分CA1和CA2锥体神经元中，以及一群独特的局部回路神经元中。在齿状回中，CaBP免疫反应性非颗粒细胞存在于分子层和门区，但不包括门区边界处的锥体篮状细胞。在海马角中，CaBP阳性的非锥体神经元在CA3区比在海马结构的任何其他部位都更常见。它们集中在CA1-3区的海马层和锥体层，而在CA3的透明层和辐射层以及CA1区的分子层中仅发现少数小神经元。PV仅存在于齿状回和海马角的局部回路神经元中。在齿状回中，门区边界处的假定篮状细胞表现出PV免疫反应性。在门区和分子层中，只有相对较少的细胞对PV有免疫反应性。这些PV阳性细胞体大多位于分子层的内半部，海马裂处偶尔有水平细胞。在海马角中，CA1-3区的海马层和锥体层含有大量PV阳性细胞。在透明层、辐射层或分子层隙状层中没有PV免疫反应性细胞。在猴海马结构中，含CaBP和PV的神经元形成不同的细胞亚群。除了猴齿状回中的一种篮状细胞类型外，发现CaBP和PV阳性细胞类型在啮齿动物和灵长类动物中非常相似。
