双鞭甲藻内酯B，一种从双鞭甲藻属物种中分离得到的新型26元大环内酯类化合物

Amphidinolactone B, a new 26-membered macrolide from dinoflagellate Amphidinium sp.

作者信息

Takahashi Yohei, Kubota Takaaki, Kobayashi Jun'ichi

机构信息

Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan.

出版信息

J Antibiot (Tokyo). 2007 Jun;60(6):376-9. doi: 10.1038/ja.2007.51.

DOI:10.1038/ja.2007.51

PMID:17617695

Abstract

A new 26-membered macrolide, amphidinolactone B, has been isolated from a marine dinoflagellate Amphidinium sp., and the structure and relative stereochemistry were elucidated on the basis of spectroscopic data. Amphidinolactone B (1) showed modest cytotoxicity.

摘要

一种新的26元大环内酯类化合物——双鞭甲藻内酯B，已从海洋双鞭甲藻Amphidinium sp.中分离出来，并根据光谱数据阐明了其结构和相对立体化学。双鞭甲藻内酯B（1）表现出适度的细胞毒性。