体外红细胞生成的调节。β-肾上腺素能激动剂对红系集落形成的影响。
Modulation of in vitro erythropoiesis. The influence of beta-adrenergic agonists on erythroid colony formation.
作者信息
Brown J E, Adamson J W
出版信息
J Clin Invest. 1977 Jul;60(1):70-7. doi: 10.1172/JCI108771.
Abstract
Canine marrow erythroid colony growth is enhanced by agents linked to the adenyl cyclase/cyclic AMP (cAMP) system, including cAMP, a phosphodieterase inhibitor (RO-20-1724), cholera enterotoxin, and beta-adrenergic agonists. The adrenergic effect is mediated by receptors having beta2-subspecificity. These receptors are distinct from putative receptors for erythropoietin and those acted upon by cholera enterotoxin. In addition, the population of cells most responsive to beta-agonists is distinct from the majority of erythropoientin-responsive cells, perhaps representing a subpopulation of this class of cell. This demonstration of an adenyl cyclase-linked mechanism regulating mammalian erythroid colony growth provides a model for the modulation by other hormones or small molecules of in vitro and, perhaps, in vivo erythropoiesis.
摘要
与腺苷酸环化酶/环磷酸腺苷（cAMP）系统相关的物质，包括cAMP、一种磷酸二酯酶抑制剂（RO-20-1724）、霍乱肠毒素和β-肾上腺素能激动剂，均可增强犬类骨髓红系集落的生长。肾上腺素能效应由具有β2特异性的受体介导。这些受体与推测的促红细胞生成素受体以及受霍乱肠毒素作用的受体不同。此外，对β-激动剂反应最敏感的细胞群体与大多数促红细胞生成素反应性细胞不同，可能代表了这类细胞中的一个亚群。这种调节哺乳动物红系集落生长的腺苷酸环化酶相关机制的证明，为其他激素或小分子对体外乃至体内红细胞生成的调节提供了一个模型。
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本文引用的文献
1
2
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Nature. 1967 May 6;214(5088):597-8. doi: 10.1038/214597a0.
3
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J Cell Physiol. 1969 Jun;73(3):191-201. doi: 10.1002/jcp.1040730305.
4
Salbutamol: a new, selective beta-adrenoceptive receptor stimulant.沙丁胺醇：一种新型的选择性β-肾上腺素能受体兴奋剂。
Br J Pharmacol. 1969 Jan;35(1):141-51. doi: 10.1111/j.1476-5381.1969.tb07975.x.
5
Erythropoietin sensitivity of rat bone marrow cells separated by velocity sedimentation.通过速度沉降分离的大鼠骨髓细胞的促红细胞生成素敏感性
Cell Tissue Kinet. 1970 Jan;3(1):55-65. doi: 10.1111/j.1365-2184.1970.tb00252.x.
6
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Science. 1970 Aug 14;169(3946):691-2. doi: 10.1126/science.169.3946.691.
7
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