• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

[羟氯喹与系统性红斑狼疮:重新评估]

[Hydroxychloroquine and systemic lupus: a reappraisal].

作者信息

Costedoat-Chalumeau N, Leroux G, Amoura Z, Piette J-C

机构信息

université de Pierre-et-Marie-Curie-Paris-6, centre de référence national pour les lupus et le syndrome des antiphospholipides, centre hospitalier universitaire de la Pitié-Salpêtrière, Paris, France.

出版信息

Rev Med Interne. 2008 Sep;29(9):735-7. doi: 10.1016/j.revmed.2007.05.031. Epub 2007 Jun 21.

DOI:10.1016/j.revmed.2007.05.031
PMID:17618016
Abstract

PURPOSE

Hydroxychloroquine (HCQ) is still too often considered as a second-line treatment in systemic lupus erythematosus (SLE) patients.

KEY POINTS

Recently, interest for this drug has grown as a consequence of its favorable efficacy/toxicity ratio, its low cost and the availability of a blood measurement assay. Its efficiency has been demonstrated in the reduction of the risk of SLE flares and of overall damage accrual. The properties of HCQ also include a beneficial effect on lipid profile, and a protective effect against the occurrence of thrombotic events and of low bone mineral density related to corticosteroids. As a consequence, HCQ appears to have a protective effect on survival in people with SLE. Side-effects and contraindications are rare. Even if the incidence of retinopathy in clinical practice is very low, regular screening of this complication is required, but its modalities are not consensual.

CONCLUSION

These data are strong evidence for a wide prescription of HCQ. This should easily improve the management of our SLE patients.

摘要

目的

羟氯喹(HCQ)在系统性红斑狼疮(SLE)患者中仍常常被视为二线治疗药物。

关键点

近来,由于该药疗效/毒性比良好、成本低廉且有血液检测方法,对其的关注度有所提高。已证实其在降低SLE病情复发风险和总体损伤累积方面有效。HCQ的特性还包括对脂质状况有有益影响,以及对与皮质类固醇相关的血栓形成事件和低骨矿物质密度的发生有保护作用。因此,HCQ似乎对SLE患者的生存有保护作用。副作用和禁忌证很少见。即使临床实践中视网膜病变的发生率很低,但仍需要定期筛查这一并发症,不过其筛查方式尚无共识。

结论

这些数据有力地证明应广泛使用HCQ。这应能轻松改善我们对SLE患者的治疗。

相似文献

1
[Hydroxychloroquine and systemic lupus: a reappraisal].[羟氯喹与系统性红斑狼疮:重新评估]
Rev Med Interne. 2008 Sep;29(9):735-7. doi: 10.1016/j.revmed.2007.05.031. Epub 2007 Jun 21.
2
Hydroxychloroquine: a multifaceted treatment in lupus.羟氯喹:狼疮的多方面治疗手段
Presse Med. 2014 Jun;43(6 Pt 2):e167-80. doi: 10.1016/j.lpm.2014.03.007. Epub 2014 May 19.
3
Hydroxychloroquine in systemic lupus erythematosus (SLE).羟氯喹在系统性红斑狼疮(SLE)中的应用。
Expert Opin Drug Saf. 2017 Mar;16(3):411-419. doi: 10.1080/14740338.2017.1269168. Epub 2016 Dec 14.
4
The early protective effect of hydroxychloroquine on the risk of cumulative damage in patients with systemic lupus erythematosus.羟氯喹对系统性红斑狼疮患者累积损伤风险的早期保护作用。
J Rheumatol. 2013 Jun;40(6):831-41. doi: 10.3899/jrheum.120572. Epub 2013 Apr 15.
5
Longterm Hydroxychloroquine Therapy and Low-dose Aspirin May Have an Additive Effectiveness in the Primary Prevention of Cardiovascular Events in Patients with Systemic Lupus Erythematosus.长期使用羟氯喹治疗和低剂量阿司匹林可能对系统性红斑狼疮患者心血管事件的一级预防具有相加疗效。
J Rheumatol. 2017 Jul;44(7):1032-1038. doi: 10.3899/jrheum.161351. Epub 2017 May 15.
6
Hydroxychloroquine Serum Concentrations and Flares of Systemic Lupus Erythematosus: A Longitudinal Cohort Analysis.羟氯喹血清浓度与系统性红斑狼疮病情发作:一项纵向队列分析
Arthritis Care Res (Hoboken). 2016 Sep;68(9):1295-302. doi: 10.1002/acr.22837. Epub 2016 Jul 27.
7
Protective Effects of Hydroxychloroquine against Accelerated Atherosclerosis in Systemic Lupus Erythematosus.羟氯喹对系统性红斑狼疮加速动脉粥样硬化的保护作用。
Mediators Inflamm. 2018 Feb 18;2018:3424136. doi: 10.1155/2018/3424136. eCollection 2018.
8
A cross-sectional study of hydroxychloroquine concentrations and effects in people with systemic lupus erythematosus.羟氯喹在系统性红斑狼疮患者中的浓度及其影响的横断面研究。
Intern Med J. 2013 May;43(5):547-53. doi: 10.1111/imj.12100.
9
Low blood concentration of hydroxychloroquine is a marker for and predictor of disease exacerbations in patients with systemic lupus erythematosus.羟氯喹血液浓度低是系统性红斑狼疮患者疾病加重的一个标志及预测指标。
Arthritis Rheum. 2006 Oct;54(10):3284-90. doi: 10.1002/art.22156.
10
Determinants of hydroxychloroquine blood concentration variations in systemic lupus erythematosus.羟氯喹血药浓度在系统性红斑狼疮中的变化决定因素。
Arthritis Rheumatol. 2015 May;67(8):2176-84. doi: 10.1002/art.39194.

引用本文的文献

1
Use of hydroxychloroquine in corticodependent and recurrent scleritis.羟氯喹在皮质激素依赖型和复发性巩膜炎中的应用。
Graefes Arch Clin Exp Ophthalmol. 2013 Mar;251(3):989-90. doi: 10.1007/s00417-011-1922-3. Epub 2012 Jan 19.