Mycophenolic acid as a latent agonist of PPARgamma.

作者信息

Ubukata Makoto, Takamori Hitomi, Ohashi Misaki, Mitsuhashi Shinya, Yamashita Kaoru, Asada Tomohisa, Nakajima Noriyuki, Matsuura Nobuyasu, Tsuruga Mie, Taki Keiko, Magae Junji

机构信息

Division of Applied Bioscience, Research Faculty of Agriculture, Hokkaido University, Kita-9, Nishi-9, Sapporo, Japan.

出版信息

Bioorg Med Chem Lett. 2007 Sep 1;17(17):4767-70. doi: 10.1016/j.bmcl.2007.06.059. Epub 2007 Jun 26.

Mycophenolic acid (MPA), known as an inhibitor of inosine monophosphate dehydrogenase (IMPDH), was found to inhibit the differentiation of 3T3-L1 pre-adipocytes into mature adipocytes. Although the effect of MPA was attributed to inhibition of IMPDH, we uncovered a hidden biological property of MPA as an agonist of peroxisome proliferator activated receptor gamma (PPARgamma).