Giffard-Mena Ivone, Boulo Viviane, Aujoulat Fabien, Fowden Holly, Castille René, Charmantier Guy, Cramb Gordon
AEO team, UMR 5119 Ecolag, Université Montpellier II, Montpellier Cedex 05, 34095, France.
Comp Biochem Physiol A Mol Integr Physiol. 2007 Oct;148(2):430-44. doi: 10.1016/j.cbpa.2007.06.002. Epub 2007 Jun 12.
Euryhaline fish possess the ability to compensate for environmental salinity changes through hydro-mineral regulation. A number of proteins have been studied in order to understand water and ion exchanges, known as fish osmoregulation. Sea-bass (Dicentrarchus labrax) cDNA sequences encoding a homologue of mammalian aquaporin (termed AQP1) and a homologue of mammalian aquaglyceroporin (termed AQP3) have been isolated and sequenced. The aquaporin amino acid sequences share respectively more than 60% and 65% identity with other known aquaporins. We have shown that salinity influences aquaporin expression levels in the gill, kidney and digestive tract, the main osmoregulatory organs. AQP1 may have a major osmoregulatory role in water transport in kidney and gut in SW-acclimated fish, whereas AQP3 could be implicated in gill water transport in FW-acclimated fish.
广盐性鱼类具有通过水盐调节来补偿环境盐度变化的能力。为了理解水和离子交换（即鱼类渗透调节），人们对许多蛋白质进行了研究。已经分离并测序了编码哺乳动物水通道蛋白同系物（称为AQP1）和哺乳动物水甘油通道蛋白同系物（称为AQP3）的海鲈（欧洲鲈）cDNA序列。水通道蛋白的氨基酸序列与其他已知水通道蛋白的同源性分别超过60%和65%。我们已经表明，盐度会影响鳃、肾脏和消化道（主要的渗透调节器官）中水通道蛋白的表达水平。在适应海水的鱼类中，AQP1可能在肾脏和肠道的水运输中起主要的渗透调节作用，而AQP3可能与适应淡水的鱼类鳃的水运输有关。
