Khan Md Sakirul Islam, Tachibana Tetsuya, Hasebe Yuko, Masuda Naoto, Ueda Hiroshi
Department of Agrobiological Science, Faculty of Agriculture, Ehime University, Matsuyama 790-8566, Japan.
Comp Biochem Physiol A Mol Integr Physiol. 2007 Oct;148(2):458-62. doi: 10.1016/j.cbpa.2007.06.006. Epub 2007 Jun 19.
We investigated the effect of peripheral or central administration of N(G)-nitro-L-arginine methyl ester (L-NAME), a nitric oxide (NO) synthase inhibitor, on food intake in layer and broiler chicks (Gallus gallus). The intraperitoneal administration of L-NAME significantly decreased food intake in both broiler and layer chicks while the administration of D-NAME, an inactive form of L-NAME, had no effect. The intracerebroventricular (ICV) injection of L-NAME did not affect food intake in broiler chicks. However, ICV injection of L-NAME increased food intake in layer chicks while the injection of D-NAME had no effect. In addition to this, L-NAME-induced feeding was negated with the co-injection of L-arginine, suggesting that NO acts as a feeding-inhibitor signal in the brain of layer chicks. The present study revealed that administration of NO synthase inhibitor affected food intake in chicks, but the effect might be changed by chick strain and position of the injection.
我们研究了一氧化氮（NO）合酶抑制剂N(G)-硝基-L-精氨酸甲酯（L-NAME）外周或中枢给药对蛋鸡和肉鸡（原鸡）采食量的影响。腹腔注射L-NAME显著降低了肉鸡和蛋鸡的采食量，而注射L-NAME的无活性形式D-NAME则没有影响。脑室内（ICV）注射L-NAME对肉鸡的采食量没有影响。然而，ICV注射L-NAME增加了蛋鸡的采食量，而注射D-NAME则没有影响。除此之外，L-精氨酸共同注射可消除L-NAME诱导的采食，这表明NO在蛋鸡大脑中作为采食抑制信号起作用。本研究表明，给予NO合酶抑制剂会影响雏鸡的采食量，但这种影响可能因雏鸡品种和注射部位而改变。
