Luz Flávio Barbosa, Gaspar Neide Kalil, Gaspar Antonio Pedro, Carneiro Sueli, Ramos-e-Silva Marcia
Sector of Dermatology, University Hospital HUCFF/UFRJ and School of Medicine, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
Skinmed. 2007 Jul-Aug;6(4):172-8. doi: 10.1111/j.1540-9740.2007.05810.x.
The authors present part I of a review of multicentric reticulohistiocytosis, a rare systemic proliferative disease of histiocytes of unknown cause. It is clinically characterized by cutaneous and mucosal nodules and by osteoarticular lesions. The disease occurs in outbreaks that progress in severity, with spontaneous regression, but usually leaving incapacitating arthritis and disfiguring facial lesions. The authors discuss the historical, epidemiologic, and clinical aspects of this disease.
作者介绍了多中心网状组织细胞增生症综述的第一部分，这是一种病因不明的罕见组织细胞系统性增殖性疾病。其临床特征为皮肤和黏膜结节以及骨关节病变。该疾病呈爆发性发作，病情逐渐加重，可自发缓解，但通常会遗留导致残疾的关节炎和毁容性面部病变。作者讨论了该疾病的历史、流行病学和临床方面。
