Shahrabi Farahani Shokoufeh, Lotfalian Mohammadtaghi
Department of Oral and Maxillofacial Pathology, School of Dentistry, Shahid Sadoughi University of Medical Sciences and Health Services, Yazd, Iran.
J Contemp Dent Pract. 2007 Jul 1;8(5):85-91.
The aim of this article is to report an unusual and interesting case of non-syndromic multiple dentigerous cysts of the maxilla and mandible associated with melanin pigment and melanocytes in the epithelial lining in one of the cysts. In addition, embryologic aspect and origin of melanocytes are briefly discussed.
Dentigerous cysts are the second most common odontogenic cysts after radicular cysts. They are usually solitary with multiple cysts reported on occasion in association with syndromes. While melanocytes and melanin-pigment are widely distributed in the skin, the nervous system, certain types of mucosa, uveal tract, and other areas, they are not normally present within bone in mammals.
A 37-year-old Iranian male was referred to an oral surgeon by his dentist for evaluation and treatment of multiple cyst-like radiolucent lesions around the crowns of some unerupted permanent teeth in both maxillary and mandibular anterior areas. The biopsy revealed numerous granules of melanin-pigment distributed throughout the epithelial lining of one of these cysts in addition to the characteristic histopathologic features of adentigerous cyst. Histochemical analysis confirmed the pigment was melanin, and many of the cells containing melanin were immunohistochemically positive for s-100 protein.
Although the specific origin and pathologic significance of the melanocytes described here cannot be explained, it may be of interest for future investigations.
本文旨在报告一例上颌骨和下颌骨非综合征性多发性含牙囊肿的罕见且有趣的病例，其中一个囊肿的上皮衬里伴有黑色素沉着和黑素细胞。此外，还简要讨论了黑素细胞的胚胎学方面及起源。
含牙囊肿是继根端囊肿之后第二常见的牙源性囊肿。它们通常为单发，偶尔也有报道与综合征相关的多发性囊肿。虽然黑素细胞和黑色素在皮肤、神经系统、某些类型的黏膜、葡萄膜及其他区域广泛分布，但在哺乳动物的骨骼中通常不存在。
一名37岁的伊朗男性被其牙医转诊至口腔外科医生处，以评估和治疗上颌和下颌前部一些未萌出恒牙牙冠周围的多个囊肿样透射性病变。活检显示，除了含牙囊肿的特征性组织病理学特征外，其中一个囊肿的上皮衬里还分布有大量黑色素颗粒。组织化学分析证实该色素为黑色素，许多含黑色素的细胞免疫组化检测s-100蛋白呈阳性。
尽管此处描述的黑素细胞的具体起源和病理意义尚无法解释，但可能值得未来进一步研究。
