Zabaleta Jovanny, Schneider Barbara G, Ryckman Kelli, Hooper Pleasant F, Camargo M Constanza, Piazuelo M Blanca, Sierra Rosa A, Fontham Elizabeth T H, Correa Pelayo, Williams Scott M, Ochoa Augusto C
Stanley S. Scott Cancer Center, LSUHSC, New Orleans, LA, USA.
Cancer Immunol Immunother. 2008 Jan;57(1):107-14. doi: 10.1007/s00262-007-0358-4. Epub 2007 Jul 6.
Differences in incidence and outcome of cancer among ethnic groups may be explained by biological and/or socio-economic factors. Genetic variations that affect chronic inflammation, a potentially important risk factor for carcinogenesis, may differ across ethnic groups. Such differences may help explain cancer disparities among these groups. Single nucleotide polymorphisms (SNPs) within cytokine genes can affect cytokine levels and the degree of inflammation. Associations between cancer and some cytokine SNPs have been suggested. However, these have not been consistently replicated among populations, suggesting that SNP function may differ according to ethnicity, or that SNPs alone do not completely account for regulation of inflammation. We examined seven polymorphisms in African-American (n = 294) and Caucasian (n = 299) newborns in Louisiana: IL1B-511C > T, IL1B-31T > C, IL1B + 3954C > T, IL1RN2, IL10-1082G > A, IL10-592C > A, and TNF-308G > A. African-American newborns had significantly higher frequencies of IL1B-511T, IL1B-31C, IL10-1082A and IL10-592A alleles and complete linkage equilibrium between IL1B + 3954 and IL1B-31. In contrast, IL1B + 3954T, IL1RN2, and TNF-308A were more frequent in Caucasian newborns and exhibited strong linkage disequilibrium between IL1B + 3954 and IL1B-31. All allelic frequencies were significantly different between groups. We hypothesize that these dissimilarities may contribute to differences in the inflammatory response and cancer incidence and mortality between African-Americans and Caucasians in Louisiana.
不同种族群体之间癌症发病率和预后的差异可能由生物学和/或社会经济因素来解释。影响慢性炎症（致癌的一个潜在重要风险因素）的基因变异在不同种族群体中可能有所不同。这种差异可能有助于解释这些群体之间的癌症差异。细胞因子基因内的单核苷酸多态性（SNP）可影响细胞因子水平和炎症程度。已经有人提出癌症与某些细胞因子SNP之间存在关联。然而，这些关联在不同人群中并未得到一致的重复验证，这表明SNP的功能可能因种族而异，或者单独的SNP并不能完全解释炎症的调节。我们检测了路易斯安那州非裔美国新生儿（n = 294）和白种新生儿（n = 299）中的7种多态性：IL1B - 511C>T、IL1B - 31T>C、IL1B + 3954C>T、IL1RN2、IL10 - 1082G>A、IL10 - 592C>A和TNF - 308G>A。非裔美国新生儿中IL1B - 511T、IL1B - 31C、IL10 - 1082A和IL10 - 592A等位基因的频率显著更高，并且IL1B + 3954与IL1B - 31之间存在完全连锁平衡。相比之下，IL1B + 3954T、IL1RN2和TNF - 308A在白种新生儿中更为常见，并且IL1B + 3954与IL1B - 31之间表现出强烈的连锁不平衡。两组之间所有等位基因频率均存在显著差异。我们推测这些差异可能导致路易斯安那州非裔美国人和白种人在炎症反应以及癌症发病率和死亡率方面存在差异。
