Franck Maximilien, Tanner Kamaryn T, Tennyson Robert L, Daunizeau Camille, Ferrucci Luigi, Bandinelli Stefania, Trumble Benjamin C, Kaplan Hillard S, Aronoff Jacob E, Stieglitz Jonathan, Kraft Thomas S, Lea Amanda J, Venkataraman Vivek V, Wallace Ian J, Lim Yvonne A L, Ng Kee Seong, Yeong Joe Poh Sheng, Ho Roger, Lim Xinru, Mehrjerd Ameneh, Charalambous Eleftheria G, Aiello Allison E, Pawelec Graham, Franceschi Claudio, Hertel Johannes, Fülöp Tamàs, Lemoine Maël, Gurven Michael, Cohen Alan A
Research Center on Aging, Faculty of Medicine and Health Sciences, University of Sherbrooke, Sherbrooke, Quebec, Canada.
Robert N. Butler Columbia Aging Center, Mailman School of Public Health, Columbia University, New York, NY, USA.
Nat Aging. 2025 Jun 30. doi: 10.1038/s43587-025-00888-0.
Inflammaging, an age-associated increase in chronic inflammation, is considered a hallmark of aging. However, there is no consensus approach to measuring inflammaging based on circulating cytokines. Here we assessed whether an inflammaging axis detected in the Italian InCHIANTI dataset comprising 19 cytokines could be generalized to a different industrialized population (Singapore Longitudinal Aging Study) or to two indigenous, nonindustrialized populations: the Tsimane from the Bolivian Amazon and the Orang Asli from Peninsular Malaysia. We assessed cytokine axis structure similarity and whether the inflammaging axis replicating the InCHIANTI result increased with age or was associated with health outcomes. The Singapore Longitudinal Aging Study was similar to InCHIANTI except for IL-6 and IL-1RA. The Tsimane and Orang Asli showed markedly different axis structures with little to no association with age and no association with age-related diseases. Inflammaging, as measured in this manner in these cohorts, thus appears to be largely a byproduct of industrialized lifestyles, with major variation across environments and populations.
炎症衰老，即与年龄相关的慢性炎症增加，被认为是衰老的一个标志。然而，基于循环细胞因子来测量炎症衰老，目前尚无共识性方法。在此，我们评估了在包含19种细胞因子的意大利基安蒂研究（InCHIANTI）数据集中检测到的炎症衰老轴，是否能推广至另一个工业化人群（新加坡纵向衰老研究）或两个非工业化的原住民群体：来自玻利维亚亚马逊地区的齐曼人以及马来西亚半岛的原住民奥朗阿斯利人。我们评估了细胞因子轴结构的相似性，以及复制基安蒂研究结果的炎症衰老轴是否随年龄增长而增加，或者是否与健康结果相关。新加坡纵向衰老研究与基安蒂研究相似，只是在白细胞介素-6（IL-6）和白细胞介素-1受体拮抗剂（IL-1RA）方面有所不同。齐曼人和奥朗阿斯利人表现出明显不同的轴结构，与年龄几乎没有关联，也与年龄相关疾病无关。因此，在这些队列中以这种方式测量的炎症衰老，在很大程度上似乎是工业化生活方式的副产品，在不同环境和人群中存在很大差异。
