Saito T, Notani K, Miura H, Fukuda H, Mizuno S, Shindoh M, Amemiya A
First Department of Oral Surgery, Hokkaido University School of Dentistry, Sapporo, Japan.
Int J Oral Maxillofac Surg. 1991 Oct;20(5):259-63. doi: 10.1016/s0901-5027(05)80148-1.
DNA ploidy of 19 oral leukoplakias with and without epithelial dysplasia was investigated and the results were compared with 11 normal gingival biopsies, 14 oral benign tumours and 50 oral squamous cell carcinomas. The results suggest a possible relationship between DNA aneuploidy and oral leukoplakias or squamous cell carcinomas, as 32% of the oral leukoplakias and 48% of the oral squamous cell carcinomas were aneuploid although all the normal gingival biopsies and the benign oral tumours examined were diploid. No significant relationship was observed, however, between DNA ploidy and epithelial dysplasia in the leukoplakias.
对19例伴有或不伴有上皮发育异常的口腔白斑的DNA倍性进行了研究，并将结果与11例正常牙龈活检组织、14例口腔良性肿瘤及50例口腔鳞状细胞癌进行了比较。结果提示DNA非整倍性与口腔白斑或鳞状细胞癌之间可能存在关联，因为32%的口腔白斑和48%的口腔鳞状细胞癌为非整倍体，而所有检测的正常牙龈活检组织及口腔良性肿瘤均为二倍体。然而，在白斑中未观察到DNA倍性与上皮发育异常之间存在显著关联。
