患有潜在神经系统疾病患者的骶神经调节

Sacral nerve neuromodulation in patients with underlying neurologic disease.

作者信息

Wallace Patricia A, Lane Felicia L, Noblett Karen L

机构信息

Department of Obstetrics and Gynecology, Division of Female Pelvic Medicine and Reconstructive Surgery, University of California, Irvine, School of Medicine, Orange, CA 92868, USA.

出版信息

Am J Obstet Gynecol. 2007 Jul;197(1):96.e1-5. doi: 10.1016/j.ajog.2007.04.016.

DOI:10.1016/j.ajog.2007.04.016

PMID:17618775

Abstract

OBJECTIVE

Sacral nerve neuromodulation (SNS) is an effective treatment for lower urinary tract dysfunction. Many underlying neurologic processes affect lower urinary tract function. We present results of SNS in patients with underlying neurologic dysfunction.

STUDY DESIGN

This is a retrospective case series of 33 patients with neurologic disease and lower urinary tract dysfunction who underwent an InterStim stimulation procedure. Results were evaluated by pre- and postoperative voiding diaries. Success was defined as greater than 50% improvement.

RESULTS

Twenty-eight of 33 patients (85%) underwent implantation: 13 of 16 (81%) multiple sclerosis, 4 of 6 (67%) Parkinson disease, and 11 of 11 (100%) other neurologic disorders. Incontinence episodes per 24 hours decreased 68%, number of voids per 24 hours decreased 43%, nocturia decreased 70%, and there was a 58% reduction in intermittent self-catheterization per 24 hours. Ninety-three percent reported overall satisfaction.

CONCLUSION

Sacral nerve neuromodulation is an effective treatment for lower urinary tract dysfunction in patients with underlying neurologic disease.

摘要

目的

骶神经调节（SNS）是治疗下尿路功能障碍的一种有效方法。许多潜在的神经学过程会影响下尿路功能。我们展示了骶神经调节在伴有潜在神经功能障碍患者中的治疗结果。

研究设计

这是一项对33例患有神经疾病和下尿路功能障碍并接受InterStim刺激手术患者的回顾性病例系列研究。通过术前和术后排尿日记评估结果。成功定义为改善超过50%。

结果

33例患者中有28例（85%）接受了植入手术：16例多发性硬化症患者中的13例（81%），6例帕金森病患者中的4例（67%），以及11例其他神经疾病患者中的11例（100%）。每24小时的尿失禁发作次数减少68%，每24小时的排尿次数减少43%，夜尿减少70%，每24小时的间歇性自我导尿减少58%。93%的患者报告总体满意。