Powers Ted
Section of Molecular and Cellular Biology, College of Biological Sciences, University of California, Davis, CA 95616, USA.
Cell Metab. 2007 Jul;6(1):1-2. doi: 10.1016/j.cmet.2007.06.009.
Conservation of the rapamycin-sensitive TOR signaling network among eukaryotes has been instrumental to the rapid progress made in this field in recent years. A recent report in Molecular Cell (Urban et al., 2007) now extends this conservation to include Sch9, an AGC protein kinase family member from S. cerevisiae, which appears to be the long sought after yeast ortholog of mammalian S6 kinase 1 (S6K1) and a direct target for the rapamycin-sensitive TOR complex I.
近年来，真核生物中对雷帕霉素敏感的TOR信号网络的保守性对该领域的快速发展起到了推动作用。《分子细胞》杂志最近发表的一篇报告（Urban等人，2007年）将这种保守性扩展到了Sch9，它是酿酒酵母中的一种AGC蛋白激酶家族成员，似乎是长期以来寻找的哺乳动物S6激酶1（S6K1）的酵母直系同源物，也是对雷帕霉素敏感的TOR复合物I的直接靶点。
