Kadoya M, Ichiyama S, Nada T, Iida E, Takeuchi J
Department of Clinical Laboratory, Nagoya University Hospital.
Kansenshogaku Zasshi. 1991 Sep;65(9):1111-5. doi: 10.11150/kansenshogakuzasshi1970.65.1111.
Enterococci are important causative organisms of nosocomial infections as well as methicillin resistant Staphylococcus aureus and Pseudomonas aeruginosa. Enterococcal bacteremia has been increased in Nagoya University Hospital from April 1983 to March 1990. We analyzed the clinical backgrounds, portal of entry and mortality for the patients with Enterococcal septicemia. Thirty-four cases with enterococcal septicemia (24 Enterococcus faecalis, 10 Enterococcus faecium) were subjected in this study. Twenty-seven cases were monomicrobial septicemia and 7 cases were polymicrobial septicemia. As to the portal of entry, intra-abdominal infections in 21 cases, urinary tract infections in 4 cases, respiratory tract infections or chest tubes in 2 cases, decbitus infection in 1 case, intravascular catheter in 1 case, and unknown sources in 5 cases. Total mortality of the septicemia was 44.1%. E. faecium and Enterococcus avium were much more resistant to antimicrobial agents than E. faecalis. Enterococci with high-level resistance to gentamicin (minimal inhibitory concentration, greater than 2000 micrograms/ml) accounted for 35% of the 26 clinical isolates of enterococci.
肠球菌是医院感染的重要病原菌，与耐甲氧西林金黄色葡萄球菌和铜绿假单胞菌一样。1983年4月至1990年3月，名古屋大学医院的肠球菌血症有所增加。我们分析了肠球菌败血症患者的临床背景、感染入口和死亡率。本研究纳入了34例肠球菌败血症患者（24例粪肠球菌，10例屎肠球菌）。27例为单一微生物败血症，7例为多微生物败血症。关于感染入口，腹腔内感染21例，尿路感染4例，呼吸道感染或胸管相关感染2例，褥疮感染1例，血管内导管相关感染1例，5例感染源不明。败血症的总死亡率为44.1%。屎肠球菌和鸟肠球菌比粪肠球菌对抗菌药物的耐药性更强。对庆大霉素具有高水平耐药性（最低抑菌浓度大于2000微克/毫升）的肠球菌占26株临床分离肠球菌的35%。
