Nishi J, Yoshinaga M, Mogi A, Matsuyama K, Aihoshi S, Miyata K, Miyanohara H, Otsuji S
Department of Pediatrics, Faculty of Medicine, Kagoshima University.
Kansenshogaku Zasshi. 1991 Sep;65(9):1130-5. doi: 10.11150/kansenshogakuzasshi1970.65.1130.
Susceptibility to antibiotics of 123 MRSA strains isolated at the Kagoshima University Hospital in 1989 was examined. The results were as follows: 1) Susceptibility of MRSA strains was excellent to VCM, MINO, and RFP, followed by IMP, CLDM, and CPFX. However, most strains were resistant to PCG, MPIPC, ABPC, CET, CMZ, CZON, GM, and AMK. 2) Five strains highly resistant to RFP were isolated. Three of these strains were isolated on the ward for tuberculosis. This suggests easy development of resistance to RFP by MRSA. 3) Differences in susceptibility to antibiotics between coagulase type II and type VII strains were examined. The cumulative percentage of type II strains susceptible to CLDM (MICs less than 0.5 microgram/ml) was 15.3%, and that of type VII was 45.2%. Strains resistant to CLDM were more frequently isolated among type II than among type VII strains (p less than 0.001). A similar relationship between strains and antibiotics was also found with EM and CPEX. On the other hand, the cumulative percentage of type II strains susceptible to AMK (MICs less than 25 micrograms/ml) was 89.7%, and that of type VII was 9.7%. Strains resistant to AMK were more frequently isolated among type VII than among type II strains (p less than 0.001).
对1989年在鹿儿岛大学医院分离出的123株耐甲氧西林金黄色葡萄球菌（MRSA）进行了抗生素敏感性检测。结果如下：1）MRSA菌株对万古霉素（VCM）、米诺环素（MINO）和利福平（RFP）敏感性良好，其次是亚胺培南（IMP）、氯碳头孢（CLDM）和头孢泊肟酯（CPFX）。然而，大多数菌株对青霉素G（PCG）、美洛西林（MPIPC）、阿贝卡星（ABPC）、头孢噻肟（CET）、头孢美唑（CMZ）、头孢唑肟（CZON）、庆大霉素（GM）和阿米卡星（AMK）耐药。2）分离出5株对RFP高度耐药的菌株。其中3株是在结核病病房分离出来的。这表明MRSA容易对RFP产生耐药性。3）检测了凝固酶II型和VII型菌株之间抗生素敏感性的差异。对CLDM敏感（MIC小于0.5微克/毫升）的II型菌株累积百分比为15.3%，VII型为45.2%。II型菌株中对CLDM耐药的菌株分离频率高于VII型菌株（p小于0.001）。在厄他培南（EM）和头孢丙烯（CPEX）方面，菌株与抗生素之间也发现了类似关系。另一方面，对AMK敏感（MIC小于25微克/毫升）的II型菌株累积百分比为89.7%，VII型为9.7%。VII型菌株中对AMK耐药的菌株分离频率高于II型菌株（p小于0.001）。
