Mukae H, Iwamoto M, Takase T, Moro N, Ishino T, Doutsu Y, Kouno S, Yamaguchi K, Hirota M, Hara K
Department of Internal Medicine, Hokusyou Central Hospital.
Kansenshogaku Zasshi. 1990 Oct;64(10):1275-86. doi: 10.11150/kansenshogakuzasshi1970.64.1275.
Clinical and bacteriological studies were carried out to investigate the isolation of MRSA from clinical materials, during the 4 years from 1985 to 1988 at the Hokusho Central Hospital. The isolation frequency of MRSA from Staphylococcus aureus increased from 5.6% (3 strains) in 1985 to 50.0% (90 strains) in 1988. MRSA from sputum and pressure sore increased significantly. However MRSA from outpatient and inpatient in the ward for common people were constant, about 20%. Inpatients in the ward for aged person were increased significantly from 13.6% (3 strains) to 67.0% (67 strains). Most of the patients with positive MRSA isolation had background diseases (88.3%) and were bedridden (78.4%). Patients with cerebrovascular disease were 55.9% of all of the cases. But most of the MRSA strains were resistant to CZX, FOM, DMPPC, CMX, CEZ, CZON, CZX, most of the MRSA strains were sensitive to RFP, VCM, MINO, IPM/CS.
1985年至1988年的4年间，在北条中央医院开展了临床和细菌学研究，以调查从临床材料中分离耐甲氧西林金黄色葡萄球菌（MRSA）的情况。从金黄色葡萄球菌中分离出MRSA的频率从1985年的5.6%（3株）增至1988年的50.0%（90株）。痰液和压疮中的MRSA显著增加。然而，普通病房门诊患者和住院患者中的MRSA保持稳定，约为20%。老年病房住院患者中的MRSA从13.6%（3株）显著增至67.0%（67株）。大多数MRSA分离阳性的患者有基础疾病（88.3%）且卧床不起（78.4%）。脑血管疾病患者占所有病例的55.9%。但大多数MRSA菌株对头孢唑啉（CZX）、夫西地酸（FOM）、氯碳头孢（DMPPC）、头孢丙烯（CMX）、头孢地嗪（CEZ）、头孢唑肟（CZON）、头孢唑啉（CZX）耐药，大多数MRSA菌株对利福平（RFP）、万古霉素（VCM）、米诺环素（MINO）、亚胺培南/西司他丁（IPM/CS）敏感。
