Wilson Rebecca M, Danishefsky Samuel J
Laboratory for Bioorganic Chemistry, Sloan-Kettering Institute for Cancer Research, 1275 York Avenue, New York 10021, USA.
Chem Soc Rev. 2007 Aug;36(8):1207-26. doi: 10.1039/b611967k. Epub 2007 Jun 6.
This tutorial review provides a historical sampling of synthetic efforts undertaken in our laboratory, which have led to the total syntheses of a range of small molecule natural products of potential interest in oncology. It has become evident that natural products, and structures clearly derivable from natural products, have a remarkable record in the treatment of cancer at the clinical level. It is likely that, with the growing power of chemical synthesis, small molecule natural products will play a continuing role in providing lead anticancer compounds.
本教程综述提供了我们实验室所做合成工作的历史样本，这些工作已实现了一系列在肿瘤学方面具有潜在意义的小分子天然产物的全合成。显而易见，天然产物以及明显可从天然产物衍生而来的结构，在临床层面的癌症治疗方面有着卓越的记录。随着化学合成能力的不断增强，小分子天然产物很可能会在提供抗癌先导化合物方面继续发挥作用。
