Gazit Ehud
Department of Molecular Microbiology and Biotechnology, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv 69978, Israel.
Chem Soc Rev. 2007 Aug;36(8):1263-9. doi: 10.1039/b605536m. Epub 2007 May 2.
In this tutorial review the process and applications of peptide self-assembly into nanotubes, nanospheres, nanofibrils, nanotapes, and other ordered structures at the nano-scale are discussed. The formation of well-ordered nanostructures by a process of self-association represents the essence of modern nanotechnology. Such self-assembled structures can be formed by a variety of building blocks, both organic and inorganic. Of the organic building blocks, peptides are among the most useful ones. Peptides possess the biocompatibility and chemical diversity that are found in proteins, yet they are much more stable and robust and can be readily synthesized on a large scale. Short peptides can spontaneously associate to form nanotubes, nanospheres, nanofibrils, nanotapes, and other ordered structures at the nano-scale. Peptides can also form macroscopic assemblies such as hydrogels with nano-scale order. The application of peptide building blocks in biosensors, tissue engineering, and the development of antibacterial agents has already been demonstrated.
在本教程综述中，讨论了肽自组装成纳米管、纳米球、纳米纤维、纳米带及其他纳米级有序结构的过程与应用。通过自缔合过程形成有序纳米结构是现代纳米技术的核心。此类自组装结构可由多种有机和无机构建块形成。在有机构建块中，肽是最有用的构建块之一。肽具有蛋白质中所发现的生物相容性和化学多样性，但它们更稳定、更坚固，并且可以很容易地大规模合成。短肽可以自发缔合形成纳米管、纳米球、纳米纤维、纳米带及其他纳米级有序结构。肽还可以形成具有纳米级有序性的宏观聚集体，如水凝胶。肽构建块在生物传感器、组织工程和抗菌剂开发中的应用已经得到证实。
