Su Bai-hai, Fu Ping, Li Qiu, Tao Ye, Li Zi, Zao Hui-sha, Zhao Chang-sheng
College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, National Engineering Research Center for Biomaterials, Sichuan University, Chengdu, P.R. China.
J Mater Sci Mater Med. 2008 Feb;19(2):745-51. doi: 10.1007/s10856-007-3006-9. Epub 2007 Jul 10.
A new hemodialysis membrane manufactured by a blend of polyethersulfone (PES) and polyvinylpyrrolidone (PVP) was evaluated in vitro and in vivo. Goat was selected as the experimental animal. The clearance and the reduction ratio after the hemodialysis of small molecules (urea, creatinine, phosphate) for the PES membrane were higher in vitro than that in vivo. The reduction ratio of beta(2)-microglobulin was about 50% after the treatment for 4 h. The biocompatibility profiles of the membranes indicated slight neutropenia and platelet adhesion at the initial stage of the hemodialysis. Electrolyte, blood gas, and blood biochemistry were also analyzed before and after the treatment. The results indicated that PES hollow fiber membrane had a potential widely use for hemodialysis.
对一种由聚醚砜（PES）和聚乙烯吡咯烷酮（PVP）共混制成的新型血液透析膜进行了体外和体内评估。选用山羊作为实验动物。PES膜在体外对小分子（尿素、肌酐、磷酸盐）进行血液透析后的清除率和降低率高于体内。治疗4小时后β2-微球蛋白的降低率约为50%。这些膜的生物相容性概况表明在血液透析初期有轻微的中性粒细胞减少和血小板黏附现象。在治疗前后还分析了电解质、血气和血液生化指标。结果表明，PES中空纤维膜在血液透析方面有广泛应用的潜力。
