Jia Yue, Lu Xiaolong, Wu Chunrui, Xia Zekun, Wang Xiande
The Key Laboratory of Hollow Fiber Membrane Materials and Membrane Processes, Ministry of Education, Institute of Biological and Chemical Engineering, Tianjin Polytechnic University, Tianjin 300160, China.
Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2010 Feb;27(1):91-6.
Polyethersulfone (PES) hollow fibers were fabricated by dry-wet spinning method for hemodialysis application. The effects of additives polyethylene glycols (PEG) in the dope solution and of fiber thickness and inner diameter fiber on the membrane mechanical characters were investigated. The dialysis tests were conducted by using a simulated solution prepared by dissolving bovine serum albumin (BSA), lysozyme and urea in de-ionized water to test the effects of membrane characters and operating conditions on dialysis efficiency. The results indicated that the reduction of PEG concentration from 27.6 wt% to 24.1 wt% in the dope solution improved the clearance of toxins, but slightly decreased the mechanical characters. The reduction of fiber thickness or fiber inner diameter was found to improve the clearance of toxins by removing 64.2% of lysozyme and 89.4% of urea (membrane area 0.2 m2), whilst BSA retention was found being maintained above 98%. The dialysis efficiency was also noted to increase with the increase in the flow rate of either the simulated or the dialysate solution, or increasing the membrane area. Moreover, The result of a comparison on the clearance of toxins between commercial F60S and PES dialyzers indicated higher dialysis efficiency per area of the fabricated PES membrane.
采用干湿纺丝法制备了用于血液透析的聚醚砜（PES）中空纤维。研究了纺丝液中添加剂聚乙二醇（PEG）以及纤维厚度和内径对膜机械性能的影响。通过使用将牛血清白蛋白（BSA）、溶菌酶和尿素溶解在去离子水中制备的模拟溶液进行透析试验，以测试膜性能和操作条件对透析效率的影响。结果表明，纺丝液中PEG浓度从27.6 wt%降至24.1 wt%可提高毒素清除率，但会略微降低机械性能。发现减小纤维厚度或纤维内径可提高毒素清除率，对于溶菌酶和尿素的清除率分别达到64.2%和89.4%（膜面积0.2 m2），同时BSA截留率保持在98%以上。还注意到透析效率会随着模拟溶液或透析液流速的增加或膜面积的增大而提高。此外，商用F60S与PES透析器之间毒素清除率的比较结果表明，所制备的PES膜每单位面积具有更高的透析效率。
