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皮质类固醇与利多卡因混合液静脉阻滞治疗创伤后反射性交感神经营养不良综合征(RSDS):17例连续病例的回顾性分析

Treatment of posttraumatic reflex sympathetic dystrophy syndrome (RSDS) with intravenous blocks of a mixture of corticosteroid and lidocaine: a retrospective review of 17 consecutive cases.

作者信息

Tountas A A, Noguchi A

机构信息

Division of Orthopaedic Surgery, Northwestern General Hospital, Toronto, Ontario, Canada.

出版信息

J Orthop Trauma. 1991;5(4):412-9.

PMID:1762001
Abstract

Seventeen consecutive patients with posttraumatic reflex sympathetic dystrophy syndrome (RSDS) were treated with one or more regional i.v. blocks of methylprednisolone sodium succinate and lidocaine HCL after physical therapy and oral medications had failed to produce satisfactory relief of their symptoms. In 12 of these patients the upper extremity was affected, and in five, it was the lower extremity. A fracture of the distal radius was the most frequent predisposing event. The average delay between injury and the manifestation of RSDS was 2.5 months (range 2 days to almost 6 months). The index treatment in all cases started within 3 months of the onset of symptoms. The number of i.v. blocks given ranged from one to four (average 2.4). The side effects and complications were negligible. The treatment, which in most cases was given exclusively on an outpatient basis, was well tolerated by all patients except one. Assessment of 16 of them at 6 months showed that 11 had total or almost total relief of their symptoms. When 15 of the patients were reassessed at an average follow-up of 28 months (range 12-48 months), it was noted that none of the patients with an early satisfactory response experienced recurrence of their symptoms. The condition of the symptomatic patients in the interim had improved overall. Analysis of the cases with an unsatisfactory outcome suggested that the primary reason for failure was inadequate treatment rather than ineffectiveness of the treatment used. It was concluded that this method is simple, safe, and well tolerated and should be regarded as a first choice for posttraumatic RSDS.

摘要

17例连续性创伤后反射性交感神经营养不良综合征(RSDS)患者,在物理治疗和口服药物未能使症状得到满意缓解后,接受了一次或多次区域静脉注射琥珀酸钠甲泼尼龙和盐酸利多卡因阻滞治疗。其中12例患者上肢受累,5例患者下肢受累。桡骨远端骨折是最常见的诱发事件。受伤与RSDS表现之间的平均延迟时间为2.5个月(范围为2天至近6个月)。所有病例的首次治疗均在症状出现后3个月内开始。静脉注射阻滞的次数为1至4次(平均2.4次)。副作用和并发症可忽略不计。除1例患者外,所有患者对这种大多仅在门诊进行的治疗耐受性良好。对其中16例患者在6个月时的评估显示,11例患者的症状完全或几乎完全缓解。当对15例患者进行平均28个月(范围为12至48个月)的随访重新评估时,发现早期反应良好的患者均未出现症状复发。在此期间,有症状患者的病情总体有所改善。对治疗效果不佳病例的分析表明,治疗失败的主要原因是治疗不充分而非所用治疗方法无效。得出的结论是,这种方法简单、安全且耐受性良好,应被视为创伤后RSDS的首选治疗方法。

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Treatment of posttraumatic reflex sympathetic dystrophy syndrome (RSDS) with intravenous blocks of a mixture of corticosteroid and lidocaine: a retrospective review of 17 consecutive cases.皮质类固醇与利多卡因混合液静脉阻滞治疗创伤后反射性交感神经营养不良综合征(RSDS):17例连续病例的回顾性分析
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Treatment of complex regional pain syndrome type I of the hand with a series of intravenous regional sympathetic blocks with guanethidine and lidocaine.用胍乙啶和利多卡因进行一系列静脉区域交感神经阻滞治疗手部I型复杂性区域疼痛综合征。
Clin Rheumatol. 2006 Sep;25(5):687-93. doi: 10.1007/s10067-005-0122-0. Epub 2005 Dec 7.
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[Drug therapy in complex regional pain syndrome type I].
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Orthopade. 2004 Jul;33(7):796-803. doi: 10.1007/s00132-004-0674-8.
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Yale J Biol Med. 1995 May-Aug;68(3-4):95-9.