Wang Haibo, Cork Randall, Rao Ashock
Department of Anesthesiology, Louisiana State University Health Sciences Center, Shreveport, LA 71130, USA.
Curr Opin Anaesthesiol. 2007 Aug;20(4):311-5. doi: 10.1097/ACO.0b013e3281667777.
The current advance in development of a new generation of propofol and its clinical implications are reviewed.
All currently available formulations of propofol have side effects related to propofol itself, as well as to the emulsion delivery systems. A search for better and safer propofol continues. Improvement of the emulsion delivery systems is one of approaches, which can be achieved by identifying better inactive components, enhancing stability, and applying new technologies such as nanotechnology. Modification of chemical structure is another approach, particularly with the development of propofol prodrugs.
There is a continuous need to develop a better and safer propofol. The development of a new propofol should be focused on minimizing the unwanted side effects, while preserving the beneficial profiles. Hopefully, just such a new propofol will be available in the near future for clinical use.
综述新一代丙泊酚的研发进展及其临床意义。
目前所有可用的丙泊酚制剂都有与丙泊酚本身以及乳液输送系统相关的副作用。对更好、更安全的丙泊酚的探索仍在继续。改进乳液输送系统是方法之一，这可以通过鉴定更好的非活性成分、提高稳定性以及应用纳米技术等新技术来实现。化学结构修饰是另一种方法，特别是随着丙泊酚前药的发展。
持续需要研发更好、更安全的丙泊酚。新型丙泊酚的研发应专注于在保留有益特性的同时，尽量减少不良副作用。有望在不久的将来有这样一种新型丙泊酚可供临床使用。
