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Adv Drug Deliv Rev. 2011 May 30;63(6):441-55. doi: 10.1016/j.addr.2010.11.002. Epub 2010 Nov 29.
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Transdermal anaesthesia with lidocaine nano-formulation pretreated with low-frequency ultrasound in rats model.在大鼠模型中使用经低频超声预处理的利多卡因纳米制剂进行经皮麻醉。
J Nanosci Nanotechnol. 2009 Nov;9(11):6360-5. doi: 10.1166/jnn.2009.1343.
4
Adaptive computer control of anesthesia in humans.人体麻醉的自适应计算机控制
Comput Methods Biomech Biomed Engin. 2009 Dec;12(6):727-34. doi: 10.1080/10255840902911528.
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Prolonged duration local anesthesia with minimal toxicity.具有最小毒性的长效局部麻醉。
Proc Natl Acad Sci U S A. 2009 Apr 28;106(17):7125-30. doi: 10.1073/pnas.0900598106. Epub 2009 Apr 13.
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Development and clinical trial of nano-atropine sulfate dry powder inhaler as a novel organophosphorous poisoning antidote.新型有机磷中毒解毒剂纳米硫酸阿托品干粉吸入器的研发与临床试验
Nanomedicine. 2009 Mar;5(1):55-63. doi: 10.1016/j.nano.2008.07.001. Epub 2008 Sep 16.
7
Pi-Pi complexation of bupivacaine and analogues with aromatic receptors: implications for overdose remediation.
Int J Nanomedicine. 2007;2(3):449-59.
8
Development of a new generation of propofol.新一代丙泊酚的研发。
Curr Opin Anaesthesiol. 2007 Aug;20(4):311-5. doi: 10.1097/ACO.0b013e3281667777.
9
Three levels of neuroelectronic interfacing: silicon chips with ion channels, nerve cells, and brain tissue.神经电子接口的三个层次:带有离子通道的硅芯片、神经细胞和脑组织。
Ann N Y Acad Sci. 2006 Dec;1093:143-60. doi: 10.1196/annals.1382.011.
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麻醉学的未来。

The future of anaesthesiology.

作者信息

Agarwal Ankit

机构信息

Department of Anesthesiology, IMS, BHU, Varanasi, Uttar Pradesh, India.

出版信息

Indian J Anaesth. 2012 Nov;56(6):524-8. doi: 10.4103/0019-5049.104567.

DOI:10.4103/0019-5049.104567
PMID:23325935
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3546237/
Abstract

There was an era when bark of mandrake plant, boiled in wine was used to administer anesthesia. Ether, after reigning the kingdom of anaesthesiology for more than a century, came to be superseded by newer and newer agents. Anaesthesiology has witnessed tremendous developments since infancy. The introduction of advanced airway adjuncts, labour analgesia, patient controlled analgesia, fibreoptics, Bispectral Index monitors, workstations, simulators and robotic surgeries are only to name a further few. Anaesthesia for robotic surgery received much impetus and is still a dream to come true in many countries. But then, the rapid spin in technology and fast sophistication of medical field has even surpassed this. The next event to venture is entry of robots into human body made possible by a culmination of intricate medicine and fine technology that is Nanotechnology. This article briefly introduces the field of nanotechnology in relation to its potential benefits to the field of anaesthesiology. As with any new tecnique or application, nanotechnology as applied to anaesthesiology has tremendous potential for research and exploration. This article therefore orients the reader's mind towards the immense potential and benefits that can be tapped by carrying out further studies and experimentations.The literature was searched using databases, peer reviewed journals and books for over a period of one year (till December 2011). The search was carried out using keywords as nanotechnology, robotics, anesthesiology etc. Initially a master database was formed including human as well as animal studies. Later on the broad topic area was narrowed down to developments in nanotechnology as applied to anesthesiology. Further filtering of search results were done based on selection of researches and developments relating to local, regional and general anesthesia as well as critical care and pain and palliative care.

摘要

曾有一个时代,曼陀罗植物的树皮在酒中煮沸后被用于实施麻醉。乙醚在统治麻醉学领域一个多世纪后,逐渐被更新的药物所取代。自诞生以来,麻醉学见证了巨大的发展。先进气道辅助设备、分娩镇痛、患者自控镇痛、纤维光学、脑电双频指数监测仪、工作站、模拟器和机器人手术等的引入只是其中的一部分。机器人手术的麻醉受到了很大推动,在许多国家仍是一个有待实现的梦想。然而,技术的快速发展和医学领域的迅速精细化甚至超越了这一点。接下来即将出现的是机器人通过纳米技术这一复杂医学与精细技术的结合进入人体。本文简要介绍了纳米技术领域及其对麻醉学领域的潜在益处。与任何新技术或应用一样,应用于麻醉学的纳米技术具有巨大的研究和探索潜力。因此,本文引导读者认识到通过进一步研究和实验可以挖掘的巨大潜力和益处。我们使用数据库、同行评审期刊和书籍进行了为期一年(截至2011年12月)的文献检索。检索使用了纳米技术、机器人技术、麻醉学等关键词。最初形成了一个包括人体和动物研究的主数据库。随后,将广泛的主题领域缩小到应用于麻醉学的纳米技术发展。根据与局部、区域和全身麻醉以及重症监护、疼痛和姑息治疗相关的研究和发展选择,对检索结果进行了进一步筛选。