GPIHBP1：一种对乳糜微粒脂解过程至关重要的内皮细胞分子。
GPIHBP1: an endothelial cell molecule important for the lipolytic processing of chylomicrons.
作者信息
Young Stephen G, Davies Brandon S J, Fong Loren G, Gin Peter, Weinstein Michael M, Bensadoun André, Beigneux Anne P
机构信息
Department of Medicine/Division of Cardiology, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA.
出版信息
Curr Opin Lipidol. 2007 Aug;18(4):389-96. doi: 10.1097/MOL.0b013e3281527914.
PURPOSE OF REVIEW
To summarize recent data indicating that glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1 (GPIHBP1) plays a key role in the lipolytic processing of chylomicrons.
RECENT FINDINGS
Lipoprotein lipase hydrolyses triglycerides in chylomicrons at the luminal surface of the capillaries in heart, adipose tissue, and skeletal muscle. The endothelial cell molecule that facilitates the lipolytic processing of chylomicrons has never been clearly defined. Mice lacking GPIHBP1 manifest chylomicronemia, with plasma triglyceride levels as high as 5000 mg/dl. In wild-type mice, GPIHBP1 is expressed on the luminal surface of capillaries in heart, adipose tissue, and skeletal muscle. Cells transfected with GPIHBP1 bind both chylomicrons and lipoprotein lipase avidly.
SUMMARY
The chylomicronemia in Gpihbp1-deficient mice, the fact that GPIHBP1 is located within the lumen of capillaries, and the fact that GPIHBP1 binds lipoprotein lipase and chylomicrons suggest that GPIHBP1 is a key platform for the lipolytic processing of triglyceride-rich lipoproteins.
综述目的
总结近期数据，表明糖基磷脂酰肌醇锚定的高密度脂蛋白结合蛋白1（GPIHBP1）在乳糜微粒的脂解过程中起关键作用。
最新发现
脂蛋白脂肪酶在心脏、脂肪组织和骨骼肌毛细血管的管腔表面水解乳糜微粒中的甘油三酯。促进乳糜微粒脂解过程的内皮细胞分子一直未被明确界定。缺乏GPIHBP1的小鼠表现出乳糜微粒血症，血浆甘油三酯水平高达5000mg/dl。在野生型小鼠中，GPIHBP1在心脏、脂肪组织和骨骼肌毛细血管的管腔表面表达。转染了GPIHBP1的细胞能 avidly 结合乳糜微粒和脂蛋白脂肪酶。
总结
Gpihbp1缺陷小鼠中的乳糜微粒血症、GPIHBP1位于毛细血管管腔内这一事实以及GPIHBP1结合脂蛋白脂肪酶和乳糜微粒这一事实表明，GPIHBP1是富含甘油三酯脂蛋白脂解过程的关键平台。 （注：avidly这个词在原英文中可能有误，推测可能是avidly，这里按推测翻译为“强烈地”）
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