Bartolomeo Paolo
Inserm Unit 610 and Federation of Neurology, Salpêtrière Hospital, University Pierre and Marie Curie - Paris 6, Paris, France.
Curr Opin Neurol. 2007 Aug;20(4):381-6. doi: 10.1097/WCO.0b013e32816aa3a3.
Left visual neglect is a frequent and dramatic consequence of right hemisphere lesions. Diagnosis is important because behavioural and pharmacological treatments are available. Furthermore, neglect raises important issues concerning the brain mechanisms of consciousness, perception and attention.
Recent behavioural findings and new techniques, such as transcranial magnetic stimulation, direct cortical and subcortical stimulation during brain surgery, and diffusion tensor imaging tractography, have provided evidence relevant to the debate concerning the functional mechanisms and the anatomical bases of neglect.
Several component deficits appear to interact in producing different forms of neglect. Rather than lesions at single cortical levels, dysfunction of large-scale brain networks, often induced by white matter disconnection, may constitute the crucial antecedent of neglect signs.
左侧视觉忽视是右侧半球损伤常见且严重的后果。诊断很重要，因为有行为和药物治疗方法。此外，忽视引发了有关意识、感知和注意力的脑机制的重要问题。
近期的行为学发现以及新技术，如经颅磁刺激、脑外科手术期间的直接皮层和皮层下刺激以及弥散张量成像纤维束示踪，为有关忽视的功能机制和解剖学基础的争论提供了相关证据。
几种成分缺陷似乎相互作用，导致不同形式的忽视。忽视迹象的关键前提可能不是单个皮层水平的损伤，而是通常由白质连接中断引起的大规模脑网络功能障碍。
