Okamoto M
School of Health Sciences, Okayama University, Japan.
Jpn J Psychiatry Neurol. 1991 Jun;45(2):257-60. doi: 10.1111/j.1440-1819.1991.tb02467.x.
The role of interhemispheric pathways in generalization of partial seizures was evaluated in the kindling model of epilepsy. The generalized seizure kindled from the amygdala was asymmetrical in cats with callosal bisection, destruction of massa intermedia of the thalamus or bilateral ventral hippocampus. The generalized convulsion of amygdala kindled cats became asymmetrical or changed into partial seizures by callosal bisection. The fully-kindled amygdala seizure of a split-brain epileptic baboon and rhesus monkey was a hemiconvulsion or an asymmetrical generalized convulsion. The amygdala-kindled bisymmetrical generalized convulsion of the epileptic baboon was changed into a hemiconvulsion or an asymmetrical generalized convulsion. These results indicate that the corpus callosum plays an important, although not exclusive, role in bilateralization of epileptic activity, and its role becomes more important when the animal ascends the phylogenetic scale.
在癫痫点燃模型中评估了半球间通路在部分性癫痫发作泛化中的作用。在胼胝体二分、丘脑中间块破坏或双侧腹侧海马损伤的猫中，杏仁核点燃的全身性癫痫发作是不对称的。胼胝体二分可使杏仁核点燃猫的全身性惊厥变为不对称或转变为部分性癫痫发作。裂脑癫痫狒狒和恒河猴杏仁核完全点燃的癫痫发作是半身惊厥或不对称全身性惊厥。癫痫狒狒杏仁核点燃的双侧对称全身性惊厥变为半身惊厥或不对称全身性惊厥。这些结果表明，胼胝体在癫痫活动双侧化中起重要作用，尽管不是唯一作用，并且当动物在系统发育等级中上升时其作用变得更重要。
